Serum lipid profile abnormalities among patients with nephrotic syndrome
Journal Title: International Journal of Medicine and Biomedical Research - Year 2013, Vol 2, Issue 1
Abstract
Background: Nephrotic syndrome is a multifactorial clinical condition characterized by increased glomerular permeability with consequent massive proteinuria. Hyperlipidaemia has been found to be one of the cardinal manifestations of nephrotic syndrome. Aim: The present study was conducted to determine the lipid profile and cardiovascular risk of nephrotics in this locality. Methods: Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) as well as atherogenic index (AI), coronary risk index (CRI) and non-HDL cholesterol were determined in ninety-six subjects. Forty-eight were nephrotic patients while others were apparently healthy individuals used as controls. Result: TC, TG, and LDL-C of nephrotics was observed to be significantly higher (P<0.05) when compared with control subjects. Similarly, AI, CRI and non-HDL-C of nephrotics were observed to be significantly higher (P<0.05) when compared with control subjects. VLDL-C of both groups was observed to show no significant difference statistically (P>0.05). HDL-C of nephrotics was observed to be significantly lower (P<0.05) when compared with control subjects. Conclusion: The result indicates apparent lipid derangement in nephrotic syndrome which may lead to cardiovascular disease. We therefore recommend that full lipid panel should be included in the investigation of suspected nephrotics to complement early diagnosis of the syndrome and to prevent further complications that could arise from the syndrome.
Authors and Affiliations
Adu E. M
Keywords
Related Articles
- EP ID EP126320
- DOI http://dx.doi.org/10.14194/ijmbr.213
- Views 132
- Downloads 0
Cortisol plays central role in biochemical changes during pregnancy
Background: Pregnancy is known to alter the feedback effect of cortisol on ACTH secretion and reduce the effectiveness of cortisol in inhibiting ACTH response to hypertension. The mechanism and physiological significance...
An evaluation of the carrying angle of the elbow joint in adolescents
Background: The acute angle produced medially when the axis of the forearm deviates laterally from the long axis of the humerus, with the arm extended and the palm facing forward, is referred to as the carrying angle. Va...
Clozapine-induced atypical neuroleptic malignant syndrome
No abstract for this article
Preface to the 3rd issue of the International Journal of Medicine and Biomedical Research, 2013
No abstract for this article
Child abuse: Effects on the child and family in selected villages in Enugwu-Ukwu, Njikoka Local Government Area of Anambra, Nigeria
Background: Child abuse is a major problem that has been living with man and seen by many as one of his day to day activities. Aim: The study aimed to ascertain the practice and effects of child abuse on the child and fa...