Serum lipid profile and hepatic dysfunction in moderate plasmodium falciparum infection

Journal Title: Scientific Journal of Microbiology - Year 2013, Vol 2, Issue 8

Abstract

Plasmodiumfalciparum is one of four distinct species of the malaria parasite that afflicthumans and pose a threat to public health. The present study seeks to ascertainthe serum lipid profile and associated hepatic dysfunction of male subjectswith moderate P. falciparum infection. The patients were adults (n = 11) of21-31 years old and adolescent (n = 10) of 11-20 years old. Measurement ofparasite density of peripheral blood smear was by Giemsa stained techniques.Serum lipid profile, bilirubin concentration, aspartate and alaninetransferases activities were measured by spectrophotometric methods. Serumlipid profile of non-malarious and malarious subjects within the age bracketsof 11-20 years showed no significant difference (p > 0.05); with excerptionof serum [LDL-C] = 30.90±7.10 mg/dL and [HDL-C] = 31.10±7.12 mg/dL (p <0.05) of malarious subjects, which were below reference intervals. Lipidparameters of the various experimental groups showed strong positivecorrelations. Specifically, for subjects within age brackets of 21-31 years,[AST]non-malarious = 15.32±1.06 U/L, whereas, [AST]malarious = 15.34±0.95 U/L;p > 0.05. Also, [ALT] non-malarious = 5.13±1.88 U/L and [ALT]malarious =5.87±3.00 U/L; p > 0.05, in subjects within age brackets of 11-20 years.Serum conjugated bilirubin (CB) concentrations of non-malarious and malarioussubjects were within the range of 0.17±0.06-0.41±0.06 mg/dL; reference interval= 0.1-0.4 mg/dL; p > 0.05. However, serum total bilirubin (TB)concentrations of non-malarious subjects of the two age categories were withinnormal physiologic range. Contrary, serum TB concentrations of correspondingmalarious subjects gave values above the reference intervals (p < 0.05). Thepresent study showed moderate P. falciparum infection induced alteration ofserum lipid profile that that was not dependent on the age brackets of theindividuals and did not cause profound hepatic dysfunction in the varioussubjects. Similarly, the two categories of malarious subjects did not presentbiliary obstruction but had jaundice by virtue of their raised serum levels ofTB.

Authors and Affiliations

P. C. Chikezie*| Department of Biochemistry, Imo State University, Owerri, Nigeria., R. T. Okpara| Department of Biochemistry, University of Port-Harcourt, Port-Harcourt, Nigeria.

Keywords

Related Articles

The use of some herbs for improving the refrigerated storage stability of minced camel meat

Improving the quality of minced camel meat by adding 3% w/w of marjoram, rosemary and sage powder were investigated during refrigerated storage. Minced camel meat stored at 5°C and analyzed periodically for thiobarbituri...

Microbial diversity of oil spills and tar resistant bacteria isolated from beaches of Goa (India)

Oil contaminated samples collected from seven beaches of Goa (India) were analyzed for their microbial components. The alkaline pH, the presence of oil spill and tarball residue and high salt concentration were features...

Haematological and serum biochemistry response of finisher broiler fed graded levels of sweet potato (Ipomoea batata) meal as replacement for yellow maize

The study was conducted to find out the haematological and biochemistry response of broiler finisher birds fed different levels of sweet potato meal (SPM). The levels of sweet potato meal in the different treatment diets...

In-vitro antibacterial evaluation of ethanolic stem crude extracts of anacardium occidentale linn. (anacardiaceae) on streptococcus mutans associated with dental caries

The preliminary phytochemistry and antibacterial activity of ethanolic stem crude extracts of Anacardium occidentale on Streptococcus mutans isolated from dental caries were determined using chemical, standard microbiolo...

Isolation and identification of bacteria from upper respiratory tract of Black Bengal goat in Bangladesh and investigation of some epidemiological parameters related to pneumonia

Goat pneumonia (commonly known as goat shipping fever) is a common disease in Bangladesh affecting mostly at early age. The present study was aimed to isolation and identification of the associated bacteria and to invest...

Download PDF file
  • EP ID EP1170
  • DOI 10.14196/sjm.v2i8.935
  • Views 485
  • Downloads 23

How To Cite

P. C. Chikezie*, R. T. Okpara (2013). Serum lipid profile and hepatic dysfunction in moderate plasmodium falciparum infection. Scientific Journal of Microbiology, 2(8), 158-165. https://europub.co.uk/articles/-A-1170