Serum lipid profile in oral submucous fibrosis - A case control study
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 2
Abstract
Background: Oral Sub Mucous Fibrosis (OSMF) is a chronic, debilitating disease characterised by juxtaepithelial fibrosis of the oral cavity. It is a precancerous condition a generalized pathological state of the oral mucosa associated with a significantly increased risk of oral cancer. Lipids are major cell membrane components. The changes in serum lipid levels have long been associated with cancerous and precancerous conditions. So this study is aimed to evaluate the plasma lipid profile in OSMF patients. Objectives: The present study aimed to evaluate the alteration in serum lipid profile in OSMF and to compare them with healthy controls and to correlate the relationship between pathogenesis of OSMF and lipid profile. Materials and Methods: It is a case control study. The study included 50 diagnosed cases of OSMF and 50 matched healthy controls. Fasting venous blood of 3 ml was collected in both cases and controls and serum was separated. Fasting serum lipid profile including Total Cholesterol (TC), Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) and Tri-Glycerides (TG) were measured using automated analyser. Statistical analysis was done using student 't' test. Pearson's correlation was performed to establish the relationship between study variables. Results: The plasma total cholesterol, TG, LDL, VLDL and HDL levels were significantly reduced in patients with OSMF as compared to the control group.(p<0.005) Conclusion: Our study indicates that there is an inverse relationship between OSMF and serum lipid profile. Decrease in the lipid levels may be considered as a valuable biochemical marker in the early diagnosis and prognosis of oral malignancy.
Authors and Affiliations
Arati Ganiger, K Mallikarjuna Swamy
Keywords
Related Articles
- EP ID EP487346
- DOI 10.26611/10024210
- Views 166
- Downloads 0
A study of correlation between lipid peroxide and lipid profile in diabetic patients
Aims and Objectives: To Study Correlation between Lipid Peroxide and Lipid profile in Diabetic Patients. Methodology: Participants of the study group were selected from the outpatients population of Department of Diabeto...
Serodiagnosis of tuberculosis by indigenously developed antibody detection with Indirect ELISA
Background: India is the country with the highest burden of tuberculosis (TB). The World Health Organization (WHO) TB statistics for India for 2016 give an estimated incidence figure of 2.79 million cases of TB for India...
Serum PON-1 activity in the diabetes mellitus patients for predicting the atherogenic risk
Background: PON-1 activity has been demonstrated to be inversely related to the risk of cardiovascular disease and a reduction in PON-1 activity has been reported in states of high oxidative stress such as uncontrolled d...
Correlation of serum malondialdehyde level with components of metabolic syndrome
Background: Metabolic syndrome is one of the major public health concerns and is emerging as a pandemic. oxidative stress is a hallmark of metabolic syndrome and plays a central role in the progression of the disease. Ma...
Prevalence of Lp(a) in diabetes and normal population
Background: Lipoprotein a-Lp(a) has similar structure of LDL except it has one more Apo-A protein. It is produced in liver and it is highly atherogenic. Lp(a) is usually genetically predisposed but seemed to have associa...