Serum Melatonin Levels in Patients with Family Mediterranean Fever
Journal Title: Turkish Journal of Osteoporosis - Year 2020, Vol 26, Issue 2
Abstract
Objective: Melatonin (MLT) has been reported to play a role in the immunopathogenesis and aetiology of many chronic inflammatory diseases. Therefore, we aimed to investigate the possible relationship between disease severity and serum MLT levels in patients with Familial Mediterranean fever (FMF). Materials and Methods: A total of 30 patients diagnosed with FMF who had experienced no episodes for at least 1 month (mean age, 36.4±12.2 years; range, 19-68 years), including 14 men and 16 women, and 30 healthy controls (mean age, 38.4±12.5 years; range, 19-65 years), 12 men and 18 women, matched for age and gender, were included in this study. Demographic data, laboratory data and clinical characteristics of the participants were recorded and serum MLT levels were determined. In addition, the relationship between serum MLT level and disease severity was evaluated. Results: A significant difference was observed between the groups in terms of serum MLT levels (p<0.05). However, there were no significant relationships between serum MLT levels and demographic data, such as sex and age, and body mass index, erythrocyte sedimentation rate, C-reactive protein and fibrinogen levels and disease severity scores of the FMF patients. There was a statistically significant difference in serum MLT levels between patients having a history of acute arthritis (n=7) and those without arthritis (n=23), (p=0.019). Conclusion: Our findings suggest that MLT may play a possible role in the immunopathogenesis of FMF and those with a history of FMF-related arthritis. However, because the immune regulatory role of MLT is very complex and the mechanisms are not yet fully understood, we think that more comprehensive studies in the future are needed to confirm our findings.
Authors and Affiliations
Ayhan Kul, Nurinnisa Öztürk, Köksal Sarıhan, Fatih Baygutalp
Keywords
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- EP ID EP688759
- DOI 10.4274/tod.galenos.2020.04127
- Views 101
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