Serum procalcitonin level as a biomarker for the differential diagnosis between infectious and non-infectious systemic inflammatory response syndrome: a prospective case–control study
Journal Title: مجله علمي دانشگاه علوم پزشكي كردستان - Year 2018, Vol 23, Issue 95
Abstract
Background and Aim: Considering the importance of sepsis and its complications in the mortality of the patients admitted to different parts of hospital and the importance of early diagnosis and timely and appropriate treatment in the patients' survival, we investigated the value of procalcitonin serum level for the differential diagnosis between infectious and non-infectious SIRS in the patients referring to Tohid Hospital in Sanandaj. Material and Methods: In this descriptive analytical (case-control) study, we measured procalcitonin level in SIRS positive patients who had been referring to Tohid Hospital in Sanandaj. After obtaing the results of the lab.tests the patients were divided into two groups of infectious SIRS (case group) and non-infectious (control group) based on the final diagnosis made by our infectious diseases specialist. Patients with history of antibiotic intake within the last 48 hours, mechanical trauma, heat stroke, recent surgery, cancer and severe burn were excluded from the study. Each group consisted of 30 patients. Using SPSS software, data were analyzed by independent T-test to compare the quantitative data between the two groups. We also used Pearson correlation test to investigate the relationship between procalcitonin serum level and variables related to vital signs and blood markers. P<0.05 was considered significant. Results: Mean procalcitonin serum level in the case group was significantly higher than that in the control group, and the patients with higher respiratory rate and higher WBC counts had significant increase in procalcitonin serum level. Results of this study showed that the sensitivity, specificity and accuracy of procalcitonin test at the threshold of 0.52 ng / ml were 70%, 94% and 81.7%, respectively, and positive and negative predictive values were 75.7% and 91.3%, respectively. Conclusion: According to the results, procalcitonin level had a significant sensitivity and specificity in the differential diagnosis between infectious and non-infectious SIRS and can be considered as a diagnostic test along with other clinical and paraclinical criteria in the early stages of these disorders. This can be helpful in making early diagnosis and timely administration of medications.
Authors and Affiliations
MD Sh Afrasiabian, Medical Student H Nouri, MD K Hajibagheri, PhD E Ghaderi, MSc Sh Abdollahi, MD B Mohsenpour
Keywords
Related Articles
- EP ID EP364310
- DOI -
- Views 66
- Downloads 0
The relationship between hemoglobin level in the first trimester of pregnancy and preterm delivery
Background and Aim: Anemia is the most prevalent nutritional deficiency in the world, affecting almost 30% of people worldwide, especially the pregnant women. On the other hand preterm birth is responsible for 2/3 of th...
Reports of adverse drug reactions (ADR) and their related factors in ADR unite of Food and Drug administration Department of Kurdistan Province in 2013 and 2014
Background and Aim: Adverse drug reactions (ADR) impose costs on the health care system and affect public health. Identification, assessment and prevention of adverse drug reactions are effective factors which can influe...
The effectiveness of relaxation techniques on depression, anxiety and stress in pregnant women: based on self-efficacy theory
Background and Aim: Psychosocial variables in pregnant women, including prenatal stress, anxiety and depression are associated with maternal, infant and child health. Relaxation technique is an intervention that increase...
XML Prevalence of gastroesophageal reflux and its related factors in Sanandaj
Background and Aim: Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal diseases and its prevalence rate in various countries, including Iran has been on the rise. The aim of this study was...
A comparative study of Doppler indices of renal artry before and after extracorporeal shock wave lithotripsy in contralateral kidney
Background and Aim: Urinary stones are considered as the third most common disorder of the urinary tract. ESWL is an effective and non-invasive treatment of urinary stones that can have adverse effects on the kidneys. Ch...