Serum Procalcitonin Level is a Useful Predictor of Dilating Vesicoureteral Reflux in Patients with First Febrile Urinary Tract Infection
Journal Title: Archives of Clinical Nephrology - Year 2017, Vol 3, Issue 1
Abstract
Background: Procalcitonin (PCT) has been proposed as a novel biomarker for prediction of Vesicoureteral Reflux (VUR). Since VUR is the most important risk factor for occurrence of pyelonephritis and renal tissue inflammation, serum PCT level may have a relationship with VUR. However, literature about the relationship between procalcitonin level and VUR is scanty. Aim: We evaluated the predictive value of serum PCT level in the diagnosis of VUR in children admitted with their first febrile UTI. Methods: We investigated 140 children with the first febrile UTI (2m-10 yrs.). Serum PCT was measured before initiation of antibiotics. Standard voiding cystourethrography (VCUG) was performed in all children as the gold standard for detection of VUR. Sensitivity and specificity of a high PCT level was evaluated using the receiver operating characteristic curve. Results: Seventy three patients(52%) had no VUR, while 67patients (48%) had VUR at least in one kidney, including grade 1 to 2 in 20 patients (14.3%) and , grade 3-5 in 47 (34.7%). PCT level ranged from 0.45 ng/ml to 12.7 ng/ml and, was significantly higher with increasing the grading of VUR. Comparing procalcitonin levels with VCUG results, a sensitivity of 94% and a specificity of 72% was obtained at a procalcitonin level of 0.52 ng/ml for diagnosis dilating VUR. There was a significant correlation between PCT level and C-reactive protein. Conclusion: This study described that the PCT as an inflammatory marker with proper sensitivity, specificity, PPV and NPV seems likely beneficial to predict dilating VUR.
Authors and Affiliations
Shalaby Sherein Abdelhamid, Elsayed Mohamed Fathelbab
Keywords
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- EP ID EP344910
- DOI 10.17352/acn.000018
- Views 77
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Serum Procalcitonin Level is a Useful Predictor of Dilating Vesicoureteral Reflux in Patients with First Febrile Urinary Tract Infection
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