Serum Procalcitonin, Use of Antibiotics, and Patient Outcome
Journal Title: International Journal of Innovative Research in Medical Science - Year 2016, Vol 1, Issue 7
Abstract
Objective: To evaluate the impact of serum procalcitonin (PCT) testing on use of antibiotics and patient outcome. Design: A retrospective chart review evaluation of the patients who had a serum procalcitonin test performed at one medical center. Setting: One academic medical center, Mount Sinai Medical Center, Miami Beach. Participants: One hundred and forty four consecutive patients who had procalcitonin determined beginning in January 2014. Measurements: We analyzed patient age, mortality, length of stay in intensive care unit and total hospital stay, presence of positive blood culture, and if on antibiotics at forty- eight and one hundred and twenty hours after PCT determination. Results: There were seventy two patients with a positive PCT determination (>0.5 ng/ml) and seventy two patients with negative PCT (<0.5 ng/ml). Patients with a positive serum PCT had a longer hospital length of stay, longer length of stay in Intensive Care Unit (ICU), were more likely to have a positive blood culture, more likely to be on antibiotics at 120 hours after PCT, and had higher mortality, (p<.05). Conclusion: Serum PCT level appears to predict severity of illness, mortality, and continued use of antibiotics. Negative PCT did not predict stopping of antibiotic treatment at forty-eight hours after the test.
Authors and Affiliations
Robert C Goldszer, MD, MBA, Alexandra Franco, MD, Bryan Tolentino, MD, Denise Diaz, MD, Pooja Pundhir, MD,Diana Morlote, MD, Nancimae Miller, PhD, Lydia Howard, MD Cynthia Rivera MD, Claudio Tuda MD, Kenneth Ratzan MD, Larissa Cabarga, MD, Luigi Cubbedu, MD
Keywords
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