Serum Prohepcidin Levels in Children with Thalassemia Major and Intermedia
Journal Title: Meandros Medical and Dental Journal - Year 2017, Vol 18, Issue 1
Abstract
Objective: To determine the role of hepcidin hormone levels in iron accumulation in patients with thalassemia major (TM) and thalassemia intermedia (TI). Materials and Methods: Serum prohepcidin and ferritin levels were determined in 34 patient with TM, 10 patient with TI, who attended the Department of Pediatric Hematology Adnan Menderes University Medical Faculty and the Department of Pediatrics at Aydın Atatürk State Hospital between 1 September 2006 and 30 September 2007 and 40 control patients without infection/inflammation, hepatitis or liver failure. Serum prohepcidin levels were measured using a commercial enzyme-linked immunosorbent assay kit (DRG International, Inc. Marburg, Germany); ferritin was studied with chemiluminescence method (Immulite 2000 DPC). Results: Mean serum ferritin levels in TM, TI and control groups were 2347.97±1724.81 ng/mL (range: 144-8015 ng/mL), 1352.40±918.94 ng/mL (range: 311-3109 ng/mL), and 33.35±12.03 ng/mL (range: 20-69.1 ng/mL), respectively. Serum prohepcidin levels in the same groups were 221.78±74.38 ng/mL (range: 7l.14-446.57 ng/mL), 173.31±52.14 ng/mL (range: 100.83-267.69 ng/mL), and 218.20±50.37 ng/mL (range: 116.18-330.43 ng/mL), respectively. There was a statistically significant difference in prohepcidin levels between patients with TI and control group only (p=0.016). No correlation was found between prohepcidin and ferritin levels in all groups (r=-0.023, p=0.839). Conclusion: Low levels of prohepcidin in patients with TI may be related to increased erythropoietic activity. Prohepcidin can be an indicator of active erythropoiesis.
Authors and Affiliations
Celil Yılmaz, Yusuf Ziya Aral, Aslıhan Karul, Leyla Didem Kozacı
Keywords
Related Articles
- EP ID EP226464
- DOI 10.4274/meandros.2478
- Views 143
- Downloads 0
Evaluation of Cases Applying to Child and Adolescent Psychiatry Outpatient Clinic to Receive Medical Board Report
Objective: The aim of this study was to evaluate socio-demographic characteristics, application reasons and diagnoses of cases applying to child and adolescent psychiatry outpatient clinic in order to receive a medical b...
Evaluation of Color Stability and Surface Roughness of Bulk-Fill Resin Composites and Nanocomposites
Objective: The purpose of this study was to evaluate the color stability and surface roughness of four bulk-fill resin composites (SonicFill, Filtek Bulk Fill Flowable, X-tra fil, Filtek Bulk Fill Posterior) and three na...
Short and Medium Term Results of Posterior Segmental Instrumentation and Posterolateral Fusion in Female Patients with Spondylolisthesis: A Clinical Trial
Objective: Aim of this study was to short and medium term results of posterior segmental instrumentation and posterolateral fusion in female patients with spondylolisthesis. Materials and Methods: Patients with lumbar sp...
The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study
Objective: Bronchospasm is a very important complication that can be encountered during the post-operative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Ma...
A Rare Cause of Hyperamylasemia: Macroamylasemia
Elevated serum amylase activity is commonly seen in acute pancreatitis and salivary gland inflammation, but also rarely seen in a benign phenomenon, macroamylasemia, that does not require treatment. Hyperamylasemia is a...