Serum Protease Activity As a Marker in Patients of Acute Pancreatitis- A Hospital Based Retrospective Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Introduction: Acute pancreatitis being a frequent casuality in the surgical department with griever consequences need an early diagnosis and treatment. In a developing country it is utmost important to diagnose such case and refer it to the tertiary care hospital for further evaluation and treatment to decrease the mortality rate. With this background the present study was carried out to examine the possibility of an easily conclusive test for acute pancreatitis which can be performed at the side laboratory of any hospital. Acute pancreatitis due to various etiology was diagnosed with the classical test, depedent on amylase and lipase activity. In this study the effect of protease fraction of pancreatic enzyme (mainly trypsinogen) which produce free amino acids and small peptides (2-8 amino acids prod, protease activated product PAP) was evaluated. During a phase of acute pancreatitis these fractions are expected to reflect the effect of circulating protease activity either as a relatively direct observable parameter or as an index derived from computation of some functional test. Material and Method:- The present study was a retrospective study conducted in Guwahati Medical College and Hospital within a period of one year (from 2001-2002) . The target population was divided into two main groups of control and experimental , each comprising 20 individuals. The experimental group was assayed for serum amylase,lipase,total protein and PAP on admission and on discharge.In the control group serum amylase,lipase, total protein and PAP was estimated. As they were not admitted the estimation was done once. The serum PAP was estimated by Biuret test using semiautomatic Boehringer 4020 photometer. Result:-A highly significant PAP (P<0.001) was seen between control and patient on admission, control and patient on discharge and patient on admission and discharge. Conclusion: From the present study it could be concluded that the PAP may be regarded as a reliable index of pancreatic function, though further study with the inclusion of large no of patients is advisable to draw a positive conclusion.
Authors and Affiliations
Dr (Mrs) Reepa Borah Choudhury, Dr Deba Kumar Choudhury
Keywords
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- EP ID EP239173
- DOI 10.9790/0853-1610013943
- Views 113
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