SERUM SCLEROSTIN AND DICKKOPF-1 LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME
Journal Title: Kocatepe Medical Journal - Year 2022, Vol 23, Issue 3
Abstract
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in premenopausal women, and it is a complex syndrome affecting various systems. Numerous studies have been carried out, on the effects of PCOS on bone metabolism, but currently, there is no clear information about the risk of osteoporosis in PCOS. The wingless-type mouse mammary tumor virus integration site (Wnt) pathway plays an important role in the regulation of bone metabolism. As inhibitors of this pathway, Sclerostin (Scl) and Dickkopf-1 (DKK1) have recently become therapeutic targets for osteoporosis treatment. This study aims to determine Scl and DKK1 levels in women with PCOS. MATERIAL AND METHODS: In this study, 36 women diagnosed with PCOS and 35 healthy volunteers were examined retrospectively. Both groups were compared in terms of demographic, anthropometric, and biochemical parameters as well as Scl and DKK1 levels. RESULTS: The level of Scl was 42,68 ± 13,28 pg/mL in the PCOS group and 45,69 ± 11,79 pg/mL in the control group, indicating no statistically significant difference. The level of DKK1 was 1444,73 ± 611,30 pg/mL in the PCOS group, and 1204,26 ± 660,88 pg/mL in the control group, indicating no statistically significant difference. The body mass index (BMI) and waist to hip ratio (WHR) values of the PCOS group were higher than the control group, although these differences did not reach statistical significance. CONCLUSIONS: This study shows that there were no significant differences between women with PCOS and healthy individuals in terms of Scl and DKK1 levels. Although amenorrhea causes bone loss in PCOS patients, the positive effects of hyperandrogenemia and hyperestrogenemia on bone density can be regarded as a balancing effect.
Authors and Affiliations
Ogün BİLEN Yıldız BİLEN Mustafa EROĞLU Hakan TÜRKÖN Yasemin AKDENİZ Mehmet ASİK
Keywords
Related Articles
- EP ID EP706859
- DOI https://doi.org/10.18229/kocatepetip.833378
- Views 74
- Downloads 0
THE FREQUENCY OF LOW BACK PAIN AND FACTORS AFFECTING LOW BACK PAIN IN HEALTH CARE WORKERS: A CROSS-SECTIONAL STUDY
OBJECTIVE: Healthcare facilities, especially hospitals, carry significant risks in terms of the work environment and occupational health and safety. We aimed, in this descriptive study, to determine the frequency of low...
LUMBOSACRAL TRANSITIONAL VERTEBRA: DOES IT ACCELERATE END PLATE DEGENERATION ?
OBJECTIVE: Lumbosacral transitional vertebra (LSTV) which is one of the most common congenital abnormalities of lumbosacral junction is usually detected incidentally. LSTV may increase the motion above transitional segme...
EVALUATION OF CELL SURFACE ANTIGEN EXPRESSIONS IN CASE OF CHRONIC LYMPHOCYTIC LEUKEMIA
OBJECTIVE: Immunophenotyping is critical for the diagnosis of B cell malignancy. In this study, we aimed to evaluate the cell surface antigen expression percentages and densities by flow cytometry method in patients diag...
COMPARISON OF SCHEIMPFLUG CAMERA IMAGING PATTERNS AND PARAMETERS OF PELLUCID MARGINAL DEGENERATION AND KERATOCONUS
OBJECTIVE: This study aims to compare the topography patterns and parameters in eyes with pellucid marginal degeneration (PMD) and eyes with keratoconus (KC). MATERIAL AND METHODS: This study is a retrospective and comp...
USE OF COLCHICINE FOR POST PERICARDIECTOMY SYNDROME IN PATIENTS WITH CORONARY ARTERY BYPASS GRAFT AND ITS EFFECTS ON SURGICAL INTERVENTION
OBJECTIVE: Postpericardiotomy syndrome (PPS) continues to be one of the most common causes of morbidity after cardiac surgery despite all developments. We investigated whether colchicine is more effective than expected i...