Serum soluble ST2 as a potential mediator in prediction of heart failure after acute ST elevation myocardial infarction and primary percutaneous coronary intervention
Journal Title: The Journal of Medical Research - Year 2018, Vol 4, Issue 5
Abstract
Background: Serum soluble ST2 levels are elevated early after acute myocardial infarction (AMI) and are associated with lower pre-discharge left ventricular (LV) ejection fraction and adverse cardiovascular outcomes. Objectives: This study aimed to evaluate the efficacy of measuring serum soluble ST2 level in prediction of development of heart failure in patients with acute ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI). Methods and Results: This study included 24 STEMI patients, with their age ranged from 34 to 72 years with a mean age of 56.71±9.59 years. All of cases underwent successful PPCI. Serum soluble ST2 level was measured at index presentation and at follow up after 30 days, and assessed the cases clinically. Echocardiography are used for assessment of development of cardiac muscle dysfunction. Patients diagnosed as having HF had statistically significant higher levels of ST2 than other patients at 30 days follow up. A highly significant positive correlation was shown between ST2 level and LVMI. Serum soluble ST2 level revealed significant positive correlation with degree of diastolic dysfunction at time of presentation. Conclusions: Measurement of serum soluble ST2 level, after acute STEMI managed with primary PCI can help prediction of both early and delayed onset heart failure development.
Authors and Affiliations
Ahmed Hosny El-Adawy, Ahmed Reda Algharbawy, Tarek Elsayed Selim, Eid Mohamed Abolemaaty Daoud
Keywords
Related Articles
- EP ID EP532071
- DOI 10.31254/jmr.2018.4509
- Views 112
- Downloads 0
Nuclear morphometric application in the quantitative description of breast lesions
Morphometry is the quantitative description of geometric features of structures such as tissues, cells, nuclei, or nucleoli. One of the most important functions of morphometry in pathology is the study of nuclear morphom...
Violence in teaching establishments in the western central part of Senegal
Objectives: The objectives of this work were to clearly determine the frequency and nature of the violence, to identify the main risk factors, to identify the impact of this violence on the health of the victims and fina...
Risk factors for HIV-distal symmetrical polyneuropathy: A review
Objective: To review the risk factors of HIV distal symmetrical polyneuropathy. Methods: A MEDLINE search of the English-language literature using a combination of words (HIV, neuropathy, risk factors) was used to identi...
Tacrolimus Associated Posterior Reversible Encephalopathy Syndrome (PRES): About a case
The Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological syndrome, it may occur due to a number of causes, including the use of immunosuppressive treatments. It is a rare entity. We report here t...
Displaced intrauterine device: A retrospective study
Intrauterine contraceptive devices (IUCD) are used worldwide since 1965.The intrauterine device (copper-T) is most common method used for contraception as it is an economical and effective method. It is associated with c...