Serum syndecan-1 and apolipoprotein a1 in patients with chronic hcv infection
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2015, Vol 7, Issue 4
Abstract
Hepatitis C virus (HCV) is endemic in Egypt. Over 15% of populations of the people in Egypt are infected, this is ten times greater than in any other country in the world. To validate a simple, inexpensive, non invasive markers (Fib-4, APRI, syndecan-1 and apolipoprotein A-1(ApoA-1) for detection of liver fibrosis in patients with chronic HCV and thereby reduce the need for liver biopsy. Estimation of serum syndecan-1 and apoA-1 by ELISA were done on 20 normal healthy persons and 57 chronic hepatitis C patients, the patients were staged according to liver biopsies (Metavir fibrosis staging) (stage f1=15, f2=15, f3=14,f4= 13). The area under the receiver operating characteristic (ROC) curve (AUC) of syndecan-1=(0.72), the mean level of plasma syndecan-1 was significantly higher in chronic HCV patients when compared to control subjects (P=0.0008), but the mean level of ApoA-1 was not significantly different from that of controls (p=o.65), and it had significant negative correlation to the stage of fibrosis (AUC=0.57). Moreover the APRI and Fib-4 were proved significantly directly correlated with fibrosis stage of the studied patients. This study not reveals putative biomarkers of liver fibrosis (syndecan-1, ApoA-1 APRI, Fib-4) but also proves the differential expression of those markers in different stages of fibrosis. It is expected that combination of these novel biomarkers could be applied clinically to predict the stage of liver fibrosis without the need of liver biopsy.
Authors and Affiliations
Nagwa S. Ahmed, Mohamed Ahmed Abdelmoaty, Amira Morad, Tahia H. Saleem, Ghada M. Galal
Keywords
Related Articles
- EP ID EP405738
- DOI -
- Views 96
- Downloads 0
Malignant Melanoma Of Oral Cavity– A Brief Review
Oral Malignant Melanoma is an aggressive rare malignant disorder found mostly in gingiva and hard palate in oral cavity. At present, the clinicopathological classification of oral malignant melanoma is not yet outlined,...
Influence of smoking in clinical presentation of periodontal disease in patients with other cardiovascular risk factors
Objective: The aim of the current study was to investigate the influence of smoking in the clinical presentation of periodontal disease (PD) in patients with other cardiovascular risk factors. Methods: Patients and cont...
Long-term effects of potassium citrate therapy on hypocitraturic calcium stones: a prospective randomized study
Background: Potassium citrate effectively reduces recurrence of hypocitraturic calcium nephrolithiasis. Objective: To evaluate the impact of long-term potassium citrate therapy on urinary metabolic parameters and stone...
An interventional study to ensure timeliness of nutritional assessment among spinal cord injured patients at tertiary care hospital in India
In order to ensure compliance to nutritional screening & its documentation as nutritional assessment form within 24 hours of patient’s admission, a prospective, longitudinal study was conducted wherein medical records of...
Food intake of gestational diabetes mellitus women at omdurman maternity teaching hospital khartoum state – sudan
The objective of this study was to assess the food intake of Gestational Diabetes Mellitus (GDM) women attending Omdurman Maternity Teaching Hospital. The sample included 163 diagnosed GDM with 150 non-diabetic contr...