Serum Thyroglobulin antibody (anti-Tg) and Thyroperoxidase antibody (anti-TPO) levels in School Children from goiter endemic sub-Himalayan Tarai region of Eastern Uttar Pradesh, India
Journal Title: International Journal of Medical and Health Sciences - Year 2013, Vol 2, Issue 2
Abstract
The entire sub-Himalayan tarai (flat lands) region is in the classical goiter endemic belt of India. Siddharthnagar district in Eastern Uttar Pradesh is located in the foot-hills of the Himalayas and made up of tarai (flat lands).The present study was undertaken to evaluate the serum level of genetic markers for autoimmune thyroid disease(AITD) namely thyroglobulin antibodies (TgAb) and thyroperoxidase antibody (anti-TPO) which are implicated as goitrogenic factors for the persistence of endemic goiter during post salt iodization phase in sub-Himalayan tarai region of India. A total of 140 venous blood samples were collected from the goitrous school children of both sexes from 14 study areas of Siddharthnagar district for the measurement of thyroglobulin antibody (anti-Tg) and thyroperoxidase antibody (anti-TPO). Thyroglobulin antibody (Anti-Tg) and thyroperoxidase antibody (Anti-TPO) in serum are within normal range in almost all cases, indicating that these antibodies or genetic marker perhaps play no role in the etiopathogenesis of endemic goiter in the studied region during post salt iodization phase.
Authors and Affiliations
Aniruddha Bhattacharjee, A. K. Chandra, H. K. Tiwari, Tabarak Malik ,Chiranjit Mondal
Keywords
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