SERUM THYROID HORMONE PROFILE IN BREAST CANCER PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 6
Abstract
BACKGROUND Recent studies indicate a possible relationship between thyroid diseases and breast cancer in vivo. In addition, oestrogen-like effects of thyroid hormones on breast cancer cell growth are seen in vitro. Therefore, this prospective observational study evaluated thyroid function in breast cancer patients, women with the fibrocystic disease and healthy controls. MATERIALS AND METHODS This was a prospective observational study. Pre-treatment group consisted of breast cancer patients who at the initial time of diagnosis (n= 28), post-treatment group comprising of patients who had undergone either chemotherapy/ radiotherapy or hormone therapy for their disease (n= 37). The fibrocystic group comprising of patients with benign breast tumour (n= 21) and 51 healthy control group consisted of members of the public with no prior history of breast cancer or other cancer-related disorders (n= 51) were included in the study. Thyroid history was reported. Thyroid hormones (FT4, FT3, TSH, T3, T4) and thyroid antibodies (TPO. Ab and TG. Ab) were determined. The Kruskal-Wallis H and Mann-Whitney U tests (p < 0.005 significant) were used for statistical analysis. RESULTS Free thyroxine measurements showed significant difference comparing both CA breast patients, pre-treatment (p= 0.009) and post-treatment (p= 0.001), respectively to the control group. There was no significant difference in free thyroxine levels between fibrocystic patients and control groups (p= 0.917) as well as a non-significant difference in free thyroxine levels was found between fibrocystic patients and post-treatment CA breast patients (p= 0.079). There was no significant difference in thyroxine (T4) measurement between breast cancer groups, fibrocystic group and normal healthy control group (p > 0.05). The free triiodothyronine (T3) measurements showed no significant difference between breast cancer groups, fibrocystic group and normal healthy control group (p > 0.05). The thyrotropin (TSH) measurements showed significant difference comparing both CA breast patients, pre-treatment (p= 0.016) and post-treatment (p= 0.01) respectively to the control group. The thyroid peroxidase antibodies (anti-TPO) measurements showed no significant difference between breast cancer groups, fibrocystic group and normal healthy control group (p > 0.05). CONCLUSION The subclinical hypothyroidism was seen more frequently in breast cancer patients, changing levels of thyroid hormones suggested dysregulation in breast cancer patients. These data must be confirmed in large patient’s prospective observational study
Authors and Affiliations
Abdalla Mohammed Jarari, Nouh M. H AlJarari, Jagannadha Rao Peela, Saeid Omer Alsoaeiti, Hajar Yousef Ali, Aaren Vedangi, Anuradha Argi, Azhar Hussain
Keywords
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- EP ID EP399005
- DOI 10.14260/jemds/2018/163
- Views 78
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