Serum Vascular Endothelial Growth Factor in Children with Beta Thalassemia Major
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 12
Abstract
Introduction: Beta-thalassemia major is an autosomal recessive hereditary anemia; patients frequently end up with iron overload because of hemolysis and repeated blood transfusion. Treatment with iron chelating therapy in patients with beta-thalassemia is considered the standard care, leading to improvement of morbidity and increased rate of survival. Vascular endothelial growth factor (VEGF),is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. Aim of the work: is to assess serum Vascular Endothelial Growth Factor level in children with betathalassemia major as a marker of angiogenesis. Methods: this study was conducted upon 100 children; 50 with B thalassemia major, 50 children as a control group. Complete blood count, serum ferritin and serum VEGF level were assessed in all children. Results: Patients had significantly lower serum levels of hemoglobin and hematocrit than controls (p< 0.001), and also had significantly higher serum levels of WBCs, platelets, ferritin and VEGF than controls (p< 0.001).Serum level of VEGF was significantly higher in splenectomized patients than in nonsplenectomized patients (p< 0.001). Conclusion: Patients with beta thalassemia major had high levels of VEGF. The VEGF level was higher in splenectomised thalassemic patients than non splenectomized ones. Chelation starting age was positively correlated with VEGF level. VEGF is a reliable marker for prediction of thalassemic patients for chelation therapy.
Authors and Affiliations
Reem A. Abdel Aziz
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