Serum Visfatin as a Novel Marker of Endothelial Dysfunction in Patients with Type 2 Diabetes
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 8
Abstract
Introduction: Atherosclerotic vascular complications are the main cause of premature morbidity and mortality of patients with CKD. Endothelial dysfunction is an early predictor of atherosclerosis. Visfatin levels negatively correlated with glomerular filtration rate (GFR) and endothelial function. Aim: The aim of this study is to evaluate serum visfatin level in patients with type 2 diabetic nephropathy patients and to find its association with microalbuminuria. Material and methods: Sixty type 2 diabetic subjects (T2DM) with more than 5 year diabetic duration in the age group of 35 to 60 years and thirty age and sex matched healthy controls were selected for the study. Serum visfatin, insulin levels and urine microalbumin were assessed. Results: There was significant increase in the level of plasma visfatin, urinary visfatin in microalbuminuric diabetic patients compared to normoalbuminuric diabetic patients. Conclusion: it is presumed that Plasma visfatin can be a novel surrogate marker for the clinical assessment of endothelial dysfunction and CVD risk in type 2 diabetes.
Authors and Affiliations
K Santha, KK Perumal, S Sethupathy, K Balu Mahendran
Keywords
Related Articles
- EP ID EP431960
- DOI -
- Views 126
- Downloads 0
Sexual Dysfunction in married Female patients on Antidepressants in Kashmir Valley
Introduction: Sexual dysfunction commonly occurs during antidepressant treatment. However, the reported rates of sexual dysfunction vary across antidepressants and are typically underreported in Kashmir especially in fem...
A correlational Study of Serum Ferritin Levels with Glycemic Status in Type 2 Diabetes Mellitus
Introduction: Type 2 Diabetes Mellitus (DM) is the most common endocrine disease-a metabolic disorder of multiple etiologies. The relationship between iron metabolism and type 2 DM is bidirectional. Iron is a potent pro-...
Bladder Carcinoma - A Clinical and Pathological Correlation
Introduction: Bladder carcinoma is the 2nd most common tumour of the urinary system. Treatment of choice for muscle invasive bladder carcinoma is radical cystectomy. Aim of this study was to see the correlation between p...
Correlation of Vitamin D3 Levels and the Blood Sugar Parameters among the Patients with type 2 Diabetes Mellitus
Introduction: The extra-skeletal effects of vitamin D3 have attracted considerable interest. The identification of 1,25(OH)2D receptors and 1-α-hydroxylase expression in pancreatic beta cells, in cells of the immune syst...
A Study on Comparison between Dexmedetomidine and Magnesium Sulphate in Controlled Hypotension during Functional Endoscopic Sinus Surgery under General Anaesthesia
Introduction: Induced hypotension to minimize bleeding during functional endoscopic sinus surgery (FESS) is of vital importance to the surgeon and anesthetist to decrease the risk of complications as well as procedural f...