Serum Vitamin D Level in Oral Lichen Planus Patients of North India- A Case-Control Study.
Journal Title: Journal of Dermatologic Research And Therapy - Year 2016, Vol 1, Issue 2
Abstract
Background: Studies have unveiled lower levels of serum vitamin D in autoimmune diseases and the role of vitamin D in inhibition of helper T cells proliferation, stimulation of regulatory T cells, diminishing of B-lymphocyte differentiation and inhibition of immunoglobulin secretion has been discussed in the literature. Oral lichen planus (OLP) is an autoimmune mucocutaneous disorder in which cell mediated immunity plays an important part and so it may also be related to serum vitamin D levels. Aim: To estimate serum vitamin D in oral lichen planus patients of North India, compare it to the controls and to evaluate various factors influencing vitamin D level in OLP cases such as sun exposure, gender, psychosocial factors, meteorological influences, religion and diet. Methods and Material: Venous blood samples of 102 clinically diagnosed oral lichen planus patients and 102 age and sex matched controls were obtained for the study and serum vitamin D levels were estimated using Vitek Immunodiagnostic Assay System, an automated bench-top immuno-analyzer, based on the Enzyme Linked Fluorescent Assay. The data was analyzed using chi-squared test and t-test. Results: Mean vitamin D in OLP cases and controls was 20.40 ng/ml and 32.67 ng/ml respectively. Vitamin D3 deficiency was more in OLP cases (70.6%) as compared to controls (34.3%) and insufficiency was more in controls (35.3%) as compared to OLP cases (16.7%). These differences were statistically significant. Conclusion: Although vitamin D deficiency was found more in OLP cases pointing towards the possible co-relation of vitamin D and OLP, yet insufficiency was seen more commonly in controls which revealed that this important vitamin was lacking in North Indian population.
Authors and Affiliations
Akanksha Gupta, Ravi Prakash Sasankoti Mohan, Nagaraju Kamarthi, Sangeeta Malik, Sumit Goel
Keywords
Related Articles
- EP ID EP329169
- DOI 10.14302/issn.2471-2175.jdrt-17-1481
- Views 167
- Downloads 0
A Successful Vancomycin Treatment of Multidrug-Resistant MRSA-Associated Canine Pyoderma
Case Report This report describes a case of diffuse pyoderma in a 10-year-old female dog with hypothyroidism. A previous treatment, without an early diagnosis, including cephalosporin associated with prednisolon resulte...
A Case of Pernio Associated with Cold Agglutinin Positivity in an Unusual Location
Pernio is an inflammatory disease that is usually characterized by the development of cold-induced erythrocyanotic skin lesions located in acral regions. Diagnosis is difficult if lesions are present in rare locations. A...
Contact Hypersensitivity to Lavender Oil in Hungary: A Multicentre Survey 2013-2014
Background: Lavender has been used for centuries, but its exposure has become part of the everyday life in our days. It is used in the alternative medicine, and as a flavouring component in soaps, cosmetics and in food p...
The Combination of Fractionated Erbium:YAG Laser Skin Microporation and Topical Imiquimod Is A New, Safe And Efficient Strategy for the Treatment of Actinic Keratosis and Basal Cell Carcinoma: Report of Two Pilot Studies
No Abstract
Isotretinoin-Induced Facial Hyperpigmentation: Idiosyncratic Reaction?
Isotretinoin is notorious for having a myriad of mucocutaneous side effects including cheilitis, xerodermia, facial erythema, pruritis, hair thinning, and brittle nails, among others. Although photosensitivity is conside...