Serum Vitamin D Levels and Severity of Asthma in Children
Journal Title: Annual Research & Review in Biology - Year 2015, Vol 8, Issue 1
Abstract
Introduction: Asthma is a common chronic disease and it is a cause of attending the emergency department, hospitalization, and school absences in children. Several studies recorded in various countries report the increased prevalence of about 50% per decade for childhood asthma. Vitamin D is an essential vitamin which has effects on function of the immune system. There are Different and conflicting studies about the association between low concentration of vitamin D levels and severity of asthma in children. The aim of this study was to assess the relationship between serum vitamin D status and childhood asthma. Materials and Methods: In this analytical cross-sectional study, 134 children of 3-14 years old with asthma, who were hospitalized in 2014 in Madani Hospital in Khorramabad city, were investigated with regard to their age, gender, BMI, the use of inhaled corticosteroids, and serum levels of 25-Hydroxy Vitamin D. The variables and their possible association with vitamin D deficiency in patients were investigated, using the collected data from the questionnaires and laboratory exams. Findings: Mean age of the hospitalized children was 6.76±2.8 year. Mean serum vitamin D levels in children with asthma was, 58.8±24.7 mg/dL, regardless of its severity. Among all of the children with moderate persistent asthma, 13 subjects (52%) have had vitamin D deficiency and in children with mild persistent asthma, this value was 17.1%. In addition, 1.5% of the children with intermittent asthma have had serum vitamin D deficiency. According to Fisher's exact test, the difference in the frequency distribution of serum vitamin D status in children with asthma based on the severity of asthma was significant statistically (Pv<0.0001). In spite of lower serum vitamin D in obese and over-weighted children relative to the children with normal and low BMI, this difference was not statistically significant using one-way analysis of variance. Conclusion: In higher severities of asthma, vitamin D deficiency is more evident. Therefore, sufficient amounts of vitamin D supplementation may be effective in reducing the severity of asthma in children.
Authors and Affiliations
Ahmadipour Shokoufeh, Mohsenzadeh Azam
Keywords
Related Articles
- EP ID EP353580
- DOI 10.9734/ARRB/2015/17370
- Views 88
- Downloads 0
Assessment of Essential Minerals from Almond Fruits of Terminalia catappa Cultivated in Côte d’Ivoire
Aims: To assess the minerals nutrients in the almonds of Terminalia catappa from Côte d'Ivoire and their daily contributions in adult people’s diet. Study Design: The almonds of Terminalia catappa extracted from the dry...
All-Trans Retinoic Acid Downregulates Epidermal Growth Factor Receptor Mediated Regulation of Matrix Metalloproteinase-2 in B16F10 Murine Melanoma Cells
Aims and Study Design: Epidermal growth factor receptor (EGFR) regulates a number of cellular processes, including cell motility, proliferation, differentiation and survival. EGFR mediated signal transduction via mitogen...
A Second Collection of Monogeneans and Trematodes (Phylum Platyhelminthes) Parasitic on Some Fishes from Tigris River at Baghdad Province, Iraq
Aims: This works aims to report on the monogeneans and trematodes that infect some species of fishes from Tigris River in Baghdad Province, Iraq. Place and Duration of Study: Tigris River in Baghdad Province at three sit...
Evaluation of Antioxidant and Free Radical Scavenging Activity of Tagetes patula
In present study, the preliminary screening of Tagetes patula contains many phytochemicals. These phytochemicals are able to reduce the oxidative stress in living organisms under adverse conditions. T. patula contains hi...
Influence of Main Stem Density on Irish Potato Growth and Yield: A Review
Our review confirms that stem density is affected by seed factors, seedbed conditions and planting methods. Physiologically old seed tubers develop into a ‘weak’ stem density. A loose friable soil that is warm and moist...