Serum vitamin D levels in primary hypothyroidism
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 12
Abstract
Introduction: Hypothyroidism is a common endocrine disorder with a prevalence rate of 10.95% in India. Primary hypothyroidism is the dysfunction at the level of thyroid gland, leading to decrease secretion or action of thyroid hormones. Vitamin D deficiency/ insufficiency are very prevalent in general population. In recent years the role of Vitamin D in body was extensively researched. It has been seen that besides having role in bone metabolism, Vitamin D is involved with pathology of various chronic diseases like diabetes, psoriasis, autoimmune diseases. This study was aimed to see the relationship between primary hypothyroidism and serum Vitamin D deficiency/insufficiency. Method: It was a case control study including 57 newly diagnosed hypothyroid cases of age group 20-50 years and 29 age and sex matched controls. Patients were selected based on serum TSH levels according to ATA guidelines. Any other underlying disorder was ruled out after taking proper medical history. Serum levels of 25(OH)D was measured by ELISA. TSH and thyroid hormones were measured by ECLIA. Result: The statistical analysis was done using SPSS version 20.0 software for Windows. The hypothyroid cases showed a median value with an inter-quartile range of 14.9(13.4-21.35) for Vitamin D (ng/mL). The median value with an inter-quartile range for Vitamin D in controls was26.2 (20.45-32.8). Comparing the serum Vitamin D levels between hypothyroid group and controls, a significant p value of <0.001 was observed. Vitamin D showed a moderately negative correlation (r= -0.347) with TSH with a p value of 0.008 in hypothyroid group. Conclusion: This study showed that though Vitamin D insufficiency was present in control group but this was progressed to deficiency in hypothyroid group. The decrease in serum Vitamin D levels was proportional to increase in serum TSH levels.
Authors and Affiliations
R Priya, K C Vasudha, P Kalra
Keywords
Related Articles
- EP ID EP198738
- DOI -
- Views 87
- Downloads 0
A community based study to determine health care seeking behaviour in elderly population of rural India
Background: The number of elderly is increasing day by day due to demographic transition. In developing countries, elders form a weak group in availing of social benefits. This will result in emergence of new problems re...
A clinical study of feto-maternal outcome of tocolytic agent nifedipine as compared to Isoxsuprine Hydrochloride in preterm labour
Introduction: Preterm labor and delivery is one of the biggest challenges for obstetricians and so are the preterm babies for the pediatricians. Preterm delivery affects 11% in U.S. or even greater in developing countrie...
Determination of Placental thickness using two dimensional sonography and its relation with gestational age
Introduction: An abnormal placental size has been linked to increased perinatal complications, including IUD and IUGR. Location, size, shape and architecture of placenta are easily ascertained with 2 dimensional technolo...
Importance of HRCT for prediction of disease activity in pulmonary tuberculosis
Background: Despite all governmental efforts, tuberculosis (TB) remains a public health problem world-wide with almost 9 million new cases each year and almost 2 million TB related deaths world-wide. Aims and Objectives:...
The cervical extension of human fetal thymus
Introduction: Thymus is a primary central lymphoid organ, responsible for provision of the T- lymphocytes to the entire body. It is a soft bilobed organ consisting of a pair of laterally compressed, more or less pyramida...