Serum vitamin D levels in primary hypothyroidism
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 12
Abstract
Introduction: Hypothyroidism is a common endocrine disorder with a prevalence rate of 10.95% in India. Primary hypothyroidism is the dysfunction at the level of thyroid gland, leading to decrease secretion or action of thyroid hormones. Vitamin D deficiency/ insufficiency are very prevalent in general population. In recent years the role of Vitamin D in body was extensively researched. It has been seen that besides having role in bone metabolism, Vitamin D is involved with pathology of various chronic diseases like diabetes, psoriasis, autoimmune diseases. This study was aimed to see the relationship between primary hypothyroidism and serum Vitamin D deficiency/insufficiency. Method: It was a case control study including 57 newly diagnosed hypothyroid cases of age group 20-50 years and 29 age and sex matched controls. Patients were selected based on serum TSH levels according to ATA guidelines. Any other underlying disorder was ruled out after taking proper medical history. Serum levels of 25(OH)D was measured by ELISA. TSH and thyroid hormones were measured by ECLIA. Result: The statistical analysis was done using SPSS version 20.0 software for Windows. The hypothyroid cases showed a median value with an inter-quartile range of 14.9(13.4-21.35) for Vitamin D (ng/mL). The median value with an inter-quartile range for Vitamin D in controls was26.2 (20.45-32.8). Comparing the serum Vitamin D levels between hypothyroid group and controls, a significant p value of <0.001 was observed. Vitamin D showed a moderately negative correlation (r= -0.347) with TSH with a p value of 0.008 in hypothyroid group. Conclusion: This study showed that though Vitamin D insufficiency was present in control group but this was progressed to deficiency in hypothyroid group. The decrease in serum Vitamin D levels was proportional to increase in serum TSH levels.
Authors and Affiliations
R Priya, K C Vasudha, P Kalra
Keywords
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