Serum vitamin D status in Parkinson disease in an Indian population cohort
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 7
Abstract
Objective: Recent accumulating evidence shows that vitamin D deficiency is prevalent in individuals with Parkinson disease and the administration of vitamin D might provide symptomatic benefit and improves quality of life in PD. The purpose of the present study is to perform a meta-analysis on the 25-hydroxyvitamin D (25(OH) D) status in the Indian cohort of patients with PD. Methods: 150 cases and 200 controls between ages 50 to 80 years who attended neurology OPD from January 2016 to March 2017 at LLR Hospital, Kanpur were selected for analysis.Participants were identified with Parkinson’s disease according to MDS Clinical Diagnostic Criteria for PD. Vitamin D levels (25OHD <20 ng/mL: deficient; 20 to 30 electrochemiluminescence immunoassay and intact PTH by immunoradiometric assay. Multivariate logistic regression was used to test for associations between vitamin D and PD after adjustments were made for sex, age, smoking, alcohol use, education, BMI, and vitamin D intake and sunlight exposure. Results: Deficient and insufficient serum levels of 25-hydroxy-vitamin D3 were associated with PD in multivariate analyses with p values of less than 0.005. Total 25-hydroxy-vitamin D levels were deficient in 22% of patients with PD compared with 12% of controls.The relative risk of developing Parkinson’s disease was 67% lower for the quarter of patients with the highest vitamin D levels, compared to the quarter of patients with the lowest vitamin D. Low levels of 25-hydroxy-vitamin D3 levels were correlated with higher total Unified Parkinson’s Disease Rating Scale scores at baseline and during follow-up. Conclusions: Results of our meta-analysis show that PD patients in India had lower mean levels of 25-hydroxyvitamin D than healthy controls.
Authors and Affiliations
Dr. Gaurav Gupta
Keywords
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