Severe and Prolonged Myelosuppression during Concomitant Temozolomide and Radiotherapy Treatment in a Patient with Glioblastoma Multiforme
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2015, Vol 2, Issue 4
Abstract
Aims: We describe the case of a patient with glioblastoma (GBM) who developed severe and prolonged myelosuppression during concomitant daily temozolomide (TMZ) and radiotherapy (RT) treatment. Analysis of polymorphisms in genes correlated with TMZ-induced myelotoxicity was also performed. Presentation of the Case: A 67–year-old man with diagnosis of GBM undergoing concomitant RT-TMZ treatment developed severe and prolonged pancytopenia that led to discontinuation of TMZ and required frequent platelet and red cells transfusions. Analysis of single nucleotide polymorphisms (SNPs) in the genes NAD(P)H dehydrogenase, quinone 1 (NQO1) and glutathione S-transferase pi 1 (GSTP1) was carried out. Both SNPs were found to be wild-type. Discussion: TMZ is an oral alkylating agent used for the treatment of glioblastoma. TMZ is usually considered well tolerated and safe, with nausea and mild myelosuppression being the most common side effects. However, severe haematologic adverse events have been also reported. Recently, there has been growing interest in gene polymorphisms that might be associated with an increased risk of hematologic toxicity. Conclusion: Myelosuppression is a side effect that can occur relatively early during concomitant TMZ treatment and can negatively impact on patient’s quality of life. Further studies are warranted to find out a correlation between genetic factors and the occurrence of severe hematologic toxicity.
Authors and Affiliations
Claudia Scaringi, Vitaliana De Sanctis, Giuseppe Minniti, Raffaele Porrini, Alessia Carnevale, Maurizio Valeriani, Maria Christina Cox, Maria Antonietta Aloe Spiriti, Giovanna Gentile, Luigi Ruco, Agostino Tafuri, Riccardo Maurizi Enrici
Keywords
Related Articles
- EP ID EP343871
- DOI 10.9734/IJMPCR/2015/13957
- Views 83
- Downloads 0
Small Bowel Adenocarcinoma in a Nigerian Man: A Case Report
Malignancies of the small bowel are a rare occurrence with a worldwide incidence of less than 1.0 per 100,000 populations. Only 2% of the total annual incidence of digestive cancers occurs in the small intestine as compa...
Bactrim-induced Severe Thrombocytopenia in Pregnancy
A 29-year-old Caucasian woman at 30 weeks’ gestation presented with severe and asymptomatic thrombocytopenia with a platelet count of 17 × 109/L after completing 9 days out of a 10-day course of Bactrim DS for a nasal ab...
Papillary Glioneuronal Tumor: A Case Report and a Brief Review
Aims: Papillary glioneuronal Tumor (PGNT) is a rare, recently recognized glioneuronal tumor. To date only about 68 cases of PGNT have been reported. Although it has been regarded as a grade 1 neuronal – glial tumor by Wo...
Sickle Cell Thalassemia: A Case Report and Review of Literature
Sickle cell disease is a single gene disorder causing a debilitating systemic syndrome characterized by chronic anaemia, acute painful episodes, organ infarction and chronic organ damage and by a significant reduction in...
Torsades De Pointes Induced by Methadone and Clonazepam Use
Background: While recent data showed that illicit drug use rates at six months of treatment with either methadone or buprenorphine were comparable among patients [1] and that slow-release oral morphine was not inferior t...