Severe hypercholesterolemia mediated by lipoprotein X in a patient with cholestasis
Journal Title: Annals of Hepatology - Year 2015, Vol 14, Issue 6
Abstract
Lipoprotein X (LpX) is an abnormal lipoprotein associated with cholestasis. It is a significant cause of severe hypercholesterolemia and should always be considered in patients with cholestatic liver disease. This case highlights the significance of LpX as a cause of severe hypercholesterolemia in a patient with cholestasis secondary to a granulomatous hepatitis attributed to tuberculosis. Lipoprotein agarose gel electrophoresis and gradient gel electrophoresis were performed for the detection of LpX. The liver function tests, electrolytes, lipid profile and bile acids were also determined. Anti-tuberculous therapy was initiated and the liver functions improved with normalisation of the lipid profile.
Authors and Affiliations
Dineo Phatlhane, Annalise Zemlin
Keywords
Related Articles
- EP ID EP78524
- DOI 10.5604/16652681.1171785
- Views 115
- Downloads 0
Vitamin D deficiency and vitamin D therapy in chronic hepatitis C
[b]Background[/b]. Vitamin D has immunomodulatory properties, exerts an anti-hepatitis C virus (HCV) effect in vitro and improves response to interferon-based therapy in patients with chronic hepatitis C (CHC). Low serum...
Indications for treatment in chronic HCV infection
HCV Infection is a global burden disease and it is related to the development of progressive liver fibrosis, cirrhosis and hepatocellular carcinoma. At least 80% of the persons that have an acute infection evolve to chro...
Acute hepatitis E in Montenegro: Epidemiology, clinical and laboratory features
Objective. To evaluate the incidence, demographic, clinical and laboratory characteristics of patients with acute viral hepatitis E in Montenegro. Material and methods. A total of 400 patients with acute viral hepatitis...
Maternal separation on the ethanol-preferring adult rat liver structure
Background and rationale for the study. We designed to test whether there is interaction of maternal separation (MS) on the ethanol-preferring rats liver structure. The UCh rat pups were separated daily from their mother...
Single nucleotide polymorphisms in CXCR1 gene and its association with hepatitis B infected patients in Saudi Arabia
[b]Background/Aim[/b]. This study aims to investigate whether the SNPs of CXCR1 gene, could predict the likelihood of viral persistence and/or disease progression. [b]Material and methods[/b]. We investigated the associa...