SEVERE PNEUMONIA CAUSED BY ANTIPSIHOTIC DRUGS-WHAT DOES NOT SUIT, THE PATIENT OR THE DRUG?
Journal Title: SANAMED - Year 2018, Vol 13, Issue 3
Abstract
Introduction: Antipsychotic drugs are generally categorized as typical antipsychotics (sometimes referred to as first-generation or conventional antipsychotics, or neuroleptics) and atypical antipsychotics; both are approved for the treatment of acute and chronic psychoses (i.e, schizophrenia), mania, agitation, and other psychiatric disorders. In 2005 the US Food and Drug Administration issued a warning about the increased risk of all-cause mortality associated with atypical antipsychotic use in elderly patients with dementia. Community acquired pneumonia (CAP) was one of the most frequently reported causes of death. The same warning was extended to typical antipsychotics in 2008 with extension to people with or without dementia. Case report: We present a 65-year-old Caucasian woman who was admitted to hospital due to massive pneumonia. She was suffered forschisophrenia15-years and at moment of admission she was in remission. She had continuously high fever up to 40 degrees. All collected cultures (blood, sputum, urine,smear of aspirating catheter) were negative. She was treated with various antibiotics without improvement. After changing antipsychotic drugs, she showed slow improvement until total recovery after 3 months. Discussion and conclusion: Antipsychotic-associated CAP seems to be a clinically relevant issue in frail elderly patients, as consistently documented in several epidemiologic investigations. No clear evidence exists for an increased risk of pneumonia in younger patients treated with antipsychotics. In elderly populations, the increase in risk is dose-dependent, and is more pronounced in the early phases of treatment. Future studies should better define the mechanism underlying antipsychotic-induced pneumonia and identify subgroups of antipsychotic users at higher risk of developing pneumonia.
Authors and Affiliations
Biljana Lazovic, Ivana Blazic, Mirjana Zlatkovic Svenda, Vladimir Zugic
Keywords
Related Articles
- EP ID EP430809
- DOI 10.24125/sanamed.v13i3.257
- Views 121
- Downloads 0
LIP PITS ABSCESS: ISOLATED CONGENITAL MIDLINE UPPER LIP SINUS
Congenital midline upper lip sinuses or fistulas are exceptionally uncommon condition following abnormal fusion of embryologic structures. Here, we report a case of congenital upper lip sinus type I presented as upper ve...
FACTORS AFFECTING ANAESTHESIA PREFERENCES OF THE GRAVID WOMEN WHO ARE TO DELIVER BY CAESAREAN SECTION
Objectives: In recent years, a significant increase has been observed in the prevalence of caesarean sections (CS). Although as in many other countries, CS rates in Turkey are higher than the targeted rate. This increase...
PLACING A THREADED PLUG IN THE HOLE OF A LOCKING PLATE AT THE FRACTURE LEVEL CAN INCREASE THE RESISTANCE OF THE PLATE:A BIOMECHANICAL STUDY
Objectives: This study aimed to evaluate whether placing a threaded plug in the hole of a locking plate at the fracture level is beneficial for increasing the resistance of the plate. Methods: This experimental study an...
EFFECTIVENESS OF COMPLETE BLOOD COUNT PARAMETERS FOR PREDICTING INTRACRANIAL INJURY IN CHILDREN WITH MINOR HEAD TRAUMA
Objective: We aimed to investigate the relationship between trauma severity and platelet indices (PI) and white blood cell (WBC) count to identify traumatic brain injury (TBI) in children with minor head trauma (MHT). Ma...
SEVERE PNEUMONIA CAUSED BY ANTIPSIHOTIC DRUGS-WHAT DOES NOT SUIT, THE PATIENT OR THE DRUG?
Introduction: Antipsychotic drugs are generally categorized as typical antipsychotics (sometimes referred to as first-generation or conventional antipsychotics, or neuroleptics) and atypical antipsychotics; both are appr...