Short Course Hypofractionated Radiotherapy versus Conventional Radiotherapy for Poor Prognosis Glioblastoma Multiforme: A Randomised Controlled Trial
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 3
Abstract
ABSTRACT Introduction: Glioblastoma Multiforme (GBM) has a variegated outcome due to several prognostic factors, radiotherapy dose being one of them. Aim: To find whether short course hypofractionated Radiotherapy (RT) in poor prognosis GBM is equivalent to standard 6 weeks of RT, in terms of survival and Quality of Life (QOL). Materials and Methods: Patients of GBM belonging to Radiotherapy Oncology Group Recursive Partitioning Analysis (RTOG RPA) class IV, V and VI were prospectively randomised into study arm (35Gy in 7 fractions over 15 days) and control arm (60Gy in 30 fractions over 6 weeks). A sample size of 40 with 20 patients in each arm was decided. The changes in Karnofsky Performance Status (KPS), Clinical Performance Status (CPS) and Neurological Performance Status (NPS) were noted as an assessment of QOL. Kaplan Meier method was used to analyse the overall survival and progression free survival. Log rank test was used to test the difference between the survival curves. Results: The two arms had similar demographic profile. The survival outcomes were identical for patients in the study arm (median survival 7.2 months) and the control arm (median survival 10.4 months) with log rank p=0.09. Freedom from progression was also identical at a median value of 5.5 months vs. 3.8 months, log rank p=0.34. The two arms had no difference in terms of QOL i.e., KPS, CPS and NPS. Conclusion: Hypofractionated short course RT is equivalent to standard 6 weeks RT for poor prognosis GBM patients both in terms of survival and QOL.
Authors and Affiliations
Sunil Choudhary, Neha Gupta, Punita Lal, Shaleen Kumar
Keywords
Related Articles
- EP ID EP580910
- DOI 10.7860/JCDR/2019/38056.12640
- Views 105
- Downloads 0
Measurement of Health Related Quality of Life in Malaria Patients in Indonesia using EQ-5D-5L
ABSTRACT Introduction: Indonesia is one of the countries with high malaria cases. In 2017 there were at least 261,167 malaria cases nationally. West Papua is included in the 3 major provinces with the highest incidence o...
Accuracy of Diffusion Weighted Images and MR Spectroscopy in Prostate Lesions – Our Experience with Endorectal Coil on 1.5 T MRI
Introduction: Prostatic cancer is most commonly seen in individuals greater than 65 years of age. The incidence rates are constantly increasing. Aim: To assess the accuracy of the non-contrast sequences {Diffusion Weight...
Urological Manifestations in HIV and AIDS: At Tertiary Referral Centre
Introduction: The prevalence of HIV and AIDS continues to grow worldwide. Urological manifestations of HIV and AIDS such as urolithiasis, obstructive uropathy, complicated UTI and malignancy are often first clinical sign...
Morphometric Study of Proximal and Distal End of Radius and its Clinical Significance
ABSTRACT Introduction: Radius is the bone of the forearm that is present on the lateral side. The proximal and distal end of radius are commonly susceptible to trauma, about 2-6% of fractures occur in the proximal end an...
Comparison of Polymerase Chain Reaction and Immunohistochemistry Assays for Analysing Human Papillomavirus Infection in Oral Squamous Cell Carcinoma
Introduction: Polymerase Chain Reaction (PCR) and Immunohistochemistry (IHC) are two well-known techniques used for the diagnoses of genetic diseases, tumours and different pathogens. PCR basically amplify regions of DNA...