Short-term treatment with rivastigmine and plasma levels of Ab peptides in Alzheimer’s disease
Journal Title: Folia Neuropathologica - Year 2005, Vol 43, Issue 4
Abstract
Deregulation of APP metabolism is considered to be a key pathogenic event in Alzheimer’s disease. Data from cell cultures indicate that the secretion of Ab1-42 might be inhibited by cholinesterase inhibitors, possibly via M1 receptors stimulation. Treatment with tacrine, a dual acetyl- and butyrylcholinesterase inhibitor, had no significant effect on mean plasma Ab species concentrations. However, a correlation was observed between higher drug concentrations and lower Ab levels that might indicate an effect on APP metabolism with an increased a-cleavage. Ab1-40 and Ab1-42 levels were measured in the plasma of 28 AD subjects by means of a commercially available ELISA before rivastigmine treatment and at week 2 after the first dose of the drug (3 mg/day) had been administered. Treatment with rivastigmine exhibited a significant effect on mean plasma concentrations of Ab1-42 (mean difference 7.8±8.4, t=-4.9, pmean difference 7.8±8.4, t=-4.9, p
Authors and Affiliations
Tomasz Sobow, Iwona Kloszewska
Keywords
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