Сhronic toxicity testing complex phytopoliextraction of sedative action

Journal Title: Фармацевтичний журнал - Year 2017, Vol 5, Issue 5

Abstract

Development and introduction in medical practice sedative meals on the base of complex phytopoliextracts from the domestic medical plants permitted for medical application is highly actual because of incrised incidence of abnormal psychology disorders determined by socioeconomical problems, global informative boom, ecological problems, worsening of life quality. The aim of a study – determination of the sedative phytopoliextraction complex chronic toxicity parameters in experiments after oral administration to laboratory rats. Standardized phytopoliextraction сomplex which is composed of extracts of medical plants (Valeriana officinalis L., Crataégus, Melissa officinalis L., Hypericum, Mentha piperita L., Húmulus lúpulus, Viburnum). It was determined that phytopoliextraction complex is non-toxic compound – LD50 drug after a single oral administration to mice is > 5.0 ml/kg, to rats > 10.0 ml/kg. A two-month administration of a phytopolietextraction complex in an effective and sub-toxic dose (1 ml/kg and 5 ml/kg, respectively) does not exert a toxic effect on the general state of the behavior and the increase in the weight of the animals. Phytopolietextraction complex in the subtotoxic dose does not change the functional state of the CNS in male rats, but in the effective state it increases the research activity. At the same time, it exerts a certain stimulating effect on females, due to the content of ethyl alcohol, and in a sub-toxic dose has a hypoglycemic effect largely due to the presence of ethyl alcohol. Thus, futher experiments have to be provided to learn other chronic toxicity parametres like local localirritating action, embrio- and gonadotoxicity.

Authors and Affiliations

I. L. Dyachok, O. R. Pinyazhko, O. L. Ivankiv

Keywords

Related Articles

Development of recommendations on creating local formulary drug list for children affected with gastritis and duodenitis

An urgent task is to carry out regular quality control and rational prescribing of drugs, changes to the drug formulary lists for the purpose of positive influence on the processes of pharmaceutical provision, especiall...

Study of influence of bases-carriers on biological activity f vasopressin in nasal dosage forms

Search of drugs and methods of medical treatment of mental disorders, among which the leading place belongs to nootropic medicinal products, is still of current importance. Among the latter, a special place belongs to p...

Synthesis and study of the properties of derivatives 4-phenyl-5-(1H-pyrrol-2-yl)-4H-1,2,4-triazole-3-thiols

The successful use of drugs, derivatives of 1,2,4-triazole, creates the conditionsfor the production and investigation of properties of new derivatives of this heterocyclic system. The aim of this work was synthesis and...

Synthesis, physical-chemical and biological properties of 8-R-thioderivatives of 1-benzyltheobromine

Key way for creating new medicinal drugs is structural modification of known and existent natural compounds with high biological activity. In this aspect researchers’ attention is drawn by xanthine derivatives which appe...

Tail-flick-est – aspects use in pharmacological researches

The adequate assessment of anti-nociceptive activity is important. This is necessary for development of new analgesics that exceed effectiveness and/or safety of existing analgesics, fundamental research, study specifics...

Download PDF file
  • EP ID EP556076
  • DOI 10.32352/0367-3057.5-6.17.05
  • Views 54
  • Downloads 0

How To Cite

I. L. Dyachok, O. R. Pinyazhko, O. L. Ivankiv (2017). Сhronic toxicity testing complex phytopoliextraction of sedative action. Фармацевтичний журнал, 5(5), 42-48. https://europub.co.uk/articles/-A-556076