Sickle Hyper-hemolytic Transfusion Reaction Syndrome
Journal Title: Perspectives In Medical Research - Year 2018, Vol 6, Issue 3
Abstract
Introduction :A 17-year-old female with sickle cell disease (SCD) presented with vasoocclusive crisis and jaundice, she received conventional treatment and one unit of compatible PRBC after a negative antibody screen was documented. After 48hrs of receiving a blood transfusion, her clinical picture was consistent with hemolysis. Immunohematology workup demonstrated evidence of a new antibody i.e anti-E. Delayed hemolytic transfusion reaction (DHTR) is a well-known complication of RBC transfusion. As her hemoglobin was declining , she was transfused with E antigen negative PRBCs. Despite this, hemolysis was ongoing and accelerated. Thus she was treated with steroids for presumed hyperhemolysis. Clinicians should have a high index of suspicion for hyperhemolysis in sickle cell patients with evidence of hemolysis after a recent transfusion. Differentiating hyperhemolysis from other hemolytic syndromes in SCD patient is critical; transfusions in a hyperhemolytic episode can accelerate hemolysis causing life-threatening anemia.
Authors and Affiliations
Neha Hurkat
Keywords
Related Articles
- EP ID EP306777
- DOI -
- Views 143
- Downloads 0
Posterior Reversible Encephalopathy Syndrome
Posterior reversible encephalopathy syndrome (PRES) also known as hypertensive encephalopathy is a clinico radiological entity. Eclampsia is one of the important causes. Most of the patients have severe hypertension, som...
Hemichorea-Hemiballismus syndrome in Ketotic hyperglycemia
Introduction: Diabetes mellitus is a common disorder in Asian people occasionally presenting with unusual manifestations such as hemichorea-hemiballismus (HC-HB) is a rare manifestation of primary diabetes mellitus. Sinc...
Vitamin D - A sunshine harmone
Vitamin D was considered only as a vitamin, but its role as a Preprohormone is gaining importance due to its wide range of non-calcemic benefits. So, it should be better addressed as a Sunshine Hormone rather than a vita...
Comparative evolution of serological tests in the diagnosis of Syphilis
Background: Diagnostic and therapeutic approaches in syphilis show wide variation. The use of only one type of serologic test is insufficient for diagnosis. Objective :The aim of the study was to review serologic data...
Gender preference and family planning decisions : A cross- sectional study among eligible couples staying in slum area of Eastern India
Background : The population clock on every day morning, shows that in spite of so many family planning projects, the population of India is increasing at rapid rate. objectives: To find out the socio demographic and fe...