Significance of Beta 2-Microglobulin to predict the development of HIV/AIDS
Journal Title: International Journal of Medical and Health Research - Year 2017, Vol 3, Issue 6
Abstract
Background: Beta 2-Microglobulin (β2M) is a component of the Class I major histocompatibility molecule which is present on the surface of almost all nucleated host cells. An increase in β2M serum levels has been associated with AIDS development and death and higher concentrations are found in patients with early progression to AIDS. Objective: The aim of this study was to find out the significance and correlation between β2M and CD4+ T lymphocyte count in HIV/AIDS progression. Materials and Methods: One hundred forty HIV seropositive patients were enrolled over a period of one year. Blood sample was collected in K2 EDTA vial to carry out CD4+ T lymphocyte count and in plain vial for Beta 2-Microglobulin. Pearson correlation was used to calculate the relationship between β2M and CD4+ T lymphocyte count. Results: A significant negative correlation was observed between CD4+ T lymphocyte count and β2M with spearman correlation (r= -0.632) The mean value of β2M is simultaneously increased in serum as their CD4+ T lymphocyte counts declined in HIV infected patients.. Conclusion: β2M is a sensitive surrogate marker for predicting the extent and severity of HIV infection.
Authors and Affiliations
Md. Khalid Hassan, Babita Sharma, Jitendra Panda, Nitya Vyas
A study on blood urea and serum creatinine in diabetes mellitus from Sangareddy District, Telangana, India
This study was conducted in the Department of Biochemistry, M.N.R. Medical College, Sangareddy District, Telangana, India, comprising of n=50 subjects known Diabetes mellitus patients with age range 40 - 55 years and n=2...
Multivariate analysis of the sociodemographic predictors of grip strength in U.S. Adults
Background: Grip strength is a measure of muscular fitness and is related to many health problems in adults. The purpose of this study was to examine the independent relationship that sociodemographic predictors have on...
A study on comparison between ultrasound guided technique and peripheral nerve stimulator guided technique in performing brachial plexus block (supraclavicular approach) for upper limb surgeries
Background: The use of a peripheral nerve stimulator (PNS) has been considered the ‘gold standard’ for performing peripheral nerve blocks for the last two decades and has been shown to be a highly effective technique for...
Evaluation of patient satisfaction with orthodontic treatment in Qassim region
Objectives: this study aimed to investigate the rate of satisfaction among patients following orthodontic treatment in Qassim region and to determine the factors that affected their satisfaction levels. Materials and Met...
Venous thromboembolic diseases to emergencies reporting other diseases
Thromboembolic venous disease is a frequent and severe disease, unfortunately still too often diagnosed late due to a polymorphism of its clinical presentation. Etiological research is necessary because it is often a rev...