SIGNIFICANCE OF CEREBROSPINAL FLUID (CSF) C-REACTIVE PROTEIN (CRP) IN VARIOUS TYPES OF MENINGITIS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 24
Abstract
BACKGROUND Meningitis often presents as a medical emergency which requires rapid and prompt diagnosis with aggressive management to select appropriate therapy to prevent mortality and long-term morbidity. Sometimes clinical signs and symptoms, results of routine CSF analysis and radiological findings are inadequate in making a definitive diagnosis of meningitis. On the other hand, tests like ELISA, Gram’s and AFB stain of CSF are although rapid techniques for detection of organism, have disadvantages of cost, availability and sensitivity respectively. With GeneXpert, diagnosis of Mycobacterium tuberculosis and RIF resistance is now available in less than 2 hours but again has disadvantage of cost and availability. In such circumstances, the determination of CSF CRP appears to provide a new dimension to the additional supportive diagnosis of the type of meningitis. METHODS The study was carried out on 90 patients admitted in the Department of Medicine, Gauhati Medical College & Hospital, Guwahati, Assam. The final diagnosis of the type of meningitis was based on the clinical criteria, biochemical, cytological & bacteriological examination of CSF. RESULTS In our study, the mean CRP in CSF of patients with bacterial meningitis, tubercular meningitis and viral meningitis were 24.00±11.17 mg/dl, 5.27±3.15 mg/dl and 2.57±3.11 respectively. The calculated p values show that the difference is statistically significant (p<0.0001) when the means of bacterial group is compared with the other two. CONCLUSION CSF CRP level can be used to differentiate bacterial meningitis from tubercular and viral meningitis.
Authors and Affiliations
Rumi Baruah, Bhaskar Baruah, Swaroop Kumar Baruah, Hafizur Rahman, Jayasri Medhi
Keywords
Related Articles
- EP ID EP667309
- DOI 10.18410/jebmh/2019/335
- Views 88
- Downloads 0
SPECIFIC LEARNING DISORDER IN CHILDREN WITH ATTENTION DEFICIT/HYPERACTIVITY DISORDER
BACKGROUND Attention Deficit/Hyperactivity Disorder (ADHD) is a behavioural and neurocognitive condition characterized by developmentally inappropriate and impairing levels of gross motor overactivity, inattention, and i...
THE COMPARATIVE ANALYSIS OF RENAL FUNCTION IN LIVER DISEASES USING COCKCROFT-GAULT FORMULAE AND CREATININE CLEARANCE
BACKGROUND Kidney dysfunction in liver disease can be due to different aetiologies and can have diverse manifestations. Most of the abnormalities of kidney function in cirrhosis are of functional origin namely, sodium re...
EFFECT ON BONE METABOLISM IN PATIENTS WITH TYPE 2 DIABETES MELLITUS OF ORAL HYPOGLYCAEMIC AGENTS
BACKGROUND This study evaluated the effect of treatment of many oral hypoglycaemic agents on bone metabolism in patients with type 2 diabetes mellitus and occurrence of osteoporosis. MATERIALS AND METHODS This cross-sect...
SMOKERS VS. NON-SMOKERS: A COMPARATIVE STUDY OF POST-OPERATIVE COMPLICATIONS
There is some evidence that smoking accelerates the ageing processes. The cardio-vascular, respiratory and even the musculoskeletal tissues are affected by these. In addition to the general health risks associated with s...
VARIATION OF VALGUS ANGLE IN PATIENTS PRESENTING FOR TOTAL KNEE ARTHROPLASTY
BACKGROUND Total Knee Arthroplasty (TKA) nowadays is a commonly used treatment for patients suffering from severe osteoarthritis. The success of TKA is influenced by a complex interaction between the bony anatomy, the ge...