Significance of Immune Response Patterns in Lymph Nodes Draining Breast Carcinoma
Journal Title: International Journal of Innovative Research in Medical Science - Year 2017, Vol 2, Issue 11
Abstract
Background: Axillary lymph node enlargement in breast cancer may be caused by metastasis or may be due to reactive hyperplasia. It is assumed that the histological analysis of the patterns in the regional lymph nodes draining the tumor could elucidate the immunological host-tumor relationship and provide additional information on patient survival. Material and Methods: Retrospective study on lymph nodes received with mastectomy specimens. The lymph nodes both involved and uninvolved by metastasis were selected. The morphological responses in the uninvolved lymph nodes were classified into groups comprising of either a single predominant pattern i.e., lymphocyte predominance, germinal centre predominance, or sinus histiocytosis according to the WHO proposal. The tumor size, grade, stage and the ER/PR and HER2-neu status were recorded and correlated with the patterns. Results: Forty six cases were studied with a total of 551 lymph nodes. Out of these, 123 lymph nodes had metastatic carcinoma & 428 lymph nodes had no metastasis. The patients were in the age range 22-78years. Most of the cases had a tumor size of 2-5 cms. Maximum cases had a microscopic grade of II and pathological TNM stage II. Sinus histiocytosis was the common pattern in all the patients followed by Germinal Centre Predominance and Lymphocyte Predominance. The predominance of the sinus histiocytosis pattern was found to be statistically significant, but there was no association with the pattern and tumor size, grade, stage, ER/PR and Her2-neu status. Conclusion: Reactive patterns in the regional lymph nodes could be helpful in providing information on patient prognosis
Authors and Affiliations
Dr. Prema Saldanha, Dr. Taqiya Nuzhath, Mr. Thrilok H
Keywords
Related Articles
- EP ID EP450734
- DOI -
- Views 59
- Downloads 0
Association of the Androgenetic Alopecia with Coronary Artery Disease: A Case Control Study
Skin is the largest vital protective organ of the body which acts as a mirror of systemic diseases. Androgenetic alopecia (AGA) is a genetically determined patterned alopecia which is linked to coronary artery disease (C...
High BODE Index Score and Low Albumin Serum Level Identify Patients with Chronic Obstructive Pulmonary Disease (COPD) at Higher Risk for Complications after Major Lung Cancer Resection: A Retrospective Study
Introduction - Lung cancer is significantly more common in patients with chronic obstructive pulmonary disease (COPD) than in those without obstruction. Of note, in COPD patients, who underwent major resection for lung c...
Thoracic Spondylolisthesis that Worsened Symptoms of the Thoracic Spinal Cord Potentially Caused by Patient Positioning During Surgery: A Case Report
Thoracic spondylolisthesis is a rare disease, but symptoms become severe once a patient develops myelopathy. We experienced a case of thoracic spondylotic myelopathy caused by mild degree of spondylolisthesis in the uppe...
Comparative Study of VIA and PAP Smear As a Screening Tool for Preinvasive and Early Invasive Cervical Cancer
Introduction - Cervical cancer is the 2nd common cancer among women worldwide. It is also the leading cause of cancer related mortality in women globally. Due to lack of effective screening program in developing countrie...
Serum Procalcitonin, Use of Antibiotics, and Patient Outcome
Objective: To evaluate the impact of serum procalcitonin (PCT) testing on use of antibiotics and patient outcome. Design: A retrospective chart review evaluation of the patients who had a serum procalcitonin test perform...