Significance of mucin expression in pancreatic intraepithelial neoplasia (PanIN) – precursor lesions of pancreatic ductal adenocarcinoma (PDAC)
Journal Title: Progress in Health Sciences - Year 2018, Vol 8, Issue 1
Abstract
Purpose: To evaluate chosen mucins (mucin 1, 4, 5AC) expression in pancreatic intraepithelial neoplasia, which is a precursor lesion of pancreatic ductal adenocarcinoma. Materials and methods: The study group included 70 patients operated on due to inflammation, cysts and pancreatic ductal adenocarcinoma with pancreatic intraepithelial neoplasia revealed additionally. Mucin 1, 4 and 5AC expression was assessed by immunohistochemical method using polyclonal antibodies. Results: Statistical analysis proved a positive correlation between the expression of mucin 1, 4 and 5AC proteins and the presence and staging of pancreatic intraepithelial neoplasia (p<0.001). Statistically significant correlations were determined between mucin 1, 4 and 5AC and the location of PanIN lesion in the pancreas. Positive correlations were found between mucin 5AC expression and the type of a basic disease (p=0.014). Differences in the expression of MUC 1, 4 and 5AC proteins between healthy pancreatic ducts and various stages of pancreatic intraepithelial neoplasia were statistically significant (p<0.001). Conclusions: Overexpression of mucin 1, 4 and 5AC is related to the presence of pancreatic intraepithelial neoplasia. This suggests that overproduction of mucus is a phenomenon occurring early in the process of carcinogenesis in the pancreas and has its beginning in precancerous lesions of an early stage.<br/><br/>
Authors and Affiliations
J. Zińczuk, K. Zaręba, A. Pryczynicz, P. Kuczyńska, Z. Boroń, W. Ustymowicz, M. Maciorkowska, S. Jelski
Keywords
Related Articles
- EP ID EP346738
- DOI -
- Views 69
- Downloads 0
Abnormalities of the corpus callosum: Magnetic resonance imaging analysis in children
Purpose: This study reports the clinical profile of children with abnormalities of the corpus callosum in magnetic resonance imaging (MRI). Materials and methods: Children with agenesis of the corpus callosum (ACC), hyp...
The role of obesity in modifying the course of periodontal diseases
Overweight and obesity constitute a serious social problem. They are considered hazards of developed countries. Overweight and obesity affect both adults and children. Numerous researches on the negative impact of obesit...
The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients
Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, d...
Lower limb oedema in vascular disease
Introduction: Lower limb oedema is a significant problem in vascular diseases. Due to the localization, it greatly hampers normal mobility affecting quality of life. Purpose: To evaluate the frequency of lower limb swel...
Medical students’ perceptions of people with disabilities
Introduction: Little is known about associations of attitudes of medical students towards people with disabilities and their life satisfaction and empathy. Purpose: To assess the social perception of people with disabili...