Significance of Nuclear Morphometry in Evaluation of Squamous Intraepithelial Lesions in Vaginal Cytology: A Case Series Study
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2019, Vol 8, Issue 3
Abstract
Context: Cervical cancer is the second leading malignancy in the women occurring worldwide. Researches based on nuclear morphometry on cervicovaginal smears are very much sparse; hence we have taken up this study. Aims: To valuate the role of nuclear morphometric parameters (nuclear radius and area) in differentiation of premalignant lesions of cervix. Settings and Design: Retrospective analysis of nuclear morphometric parameters in cervical smears of 40 cases. Methods and Material: Retrospective analysis of nuclear morphometric parameters in 40 cervical smears (20- LSIL and 20- HSIL) done at Government Kilpauk Medical College. Statistical analysis used: Independent sample t test was used for comparing radius and nuclear area in LSIL and HSIL lesions. Results: There was an appreciable difference in the area of nucleus among the premalignant lesions. The mean nuclear area in LSIL was 109 ± 7.446 um2 and HSIL was 132.48 ± 11.388 um2. Radius of the nucleus also showed appreciable difference in LSIL and HSIL cases included in our study. The mean nuclear radius in LSIL lesions was 3.78 ± 0.25 um and in HSIL lesions was 4.37 ± 0.34 um. Conclusions: Nuclear morphometry is henceforth an useful and dependable investigative tool in the differentiation of premalignant cervical lesions.
Authors and Affiliations
Vedamoorthy Ravishankar
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- EP ID EP595208
- DOI 10.21088/ijprp.2278.148X.8319.10
- Views 79
- Downloads 0
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