Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease
Journal Title: The European Research Journal - Year 2019, Vol 5, Issue 2
Abstract
Objectives: The severity of inflammation occurring during chronic obstructive pulmonary disease (COPD) is closely associated with oxidative stress. The aim of this study was to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD patients. Methods: This prospective study was performed with COPD patients presenting to the Kırıkkale University Hospital and with healthy volunteers. Subjects’ demographic data (age, sex, body mass index, and smoking status), native thiol (NT), total thiol (TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were recorded. Statistical analysis was performed with SPSS 21.0 software. Results: One hundred ninety subjects were enrolled in the study, 141 COPD patients and 49 healthy volunteers. No difference was determined between the patient and control groups in terms of age, sex or body mass index. The antioxidant markers; NT and TT levels and NT/TT ratio were significantly lower in the patient group compared to the control group (p < 0.001, p < 0.001, and p < 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT ratios were significantly higher in the patient group (p = 0.006, p = 0.003, and p = 0.003, respectively). Significant negative correlation was determined between antioxidant and oxidant parameters. Sensitivity values were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA: 77.8%. Conclusions: TDH was impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used to monitor oxidative stress emerging in COPD.
Authors and Affiliations
Oğuz Eroğlu, Nermin Dindar Badem, Ayşe Baccıoğlu, Ertan Cömertpay, Salim Neşelioğlu, Özcan Erel
Keywords
Related Articles
- EP ID EP492189
- DOI 10.18621/eurj.425178
- Views 112
- Downloads 0
Liver functions in patients with obstructive sleep apnea syndrome
Objective: Previous studies showed that obstructive sleep apnea syndrome (OSAS) was associated with liver diseases such as elevated liver enzyme levels and hepatic steatosis. The aim of this study was to assess the relat...
Tissue eosinophilia: a histopathological marker associated with stromal invasion but not histopathological grade in cutaneous squamous neoplasia
Objectives. The literature does not include any comparative study on the eosinophil count in premalignant and malignant cutaneous squamous neoplasias. Our aim was to compare the tissue eosinophilic count in actinic kerat...
An unusual intraosseous calcaneal lipoma: case report
Intraosseous lipoma, a rare primary benign tumor of the skeleton, is most commonly found in the calcaneus. It may contain homogenous fat, but it may also contain necrosis, calcification, or ossification. It usually does...
The value of cervical mediastinoscopy in the diagnosis of mediastinal lymphadenopathy
Objective. This study retrospectively evaluated mediastinoscopic interventions performed for diagnostic purposes in cases with mediastinal lesions remained undiagnosed by other diagnostic methods. Methods. We retrospecti...
Fatty necrosis of falciform ligament due to torsion mimics falciform ligament cyst on MRI
The falciform ligament which is a broad and thin peritoneal ligament, divides the left and right subphrenic compartments. Some pathologies of this ligament can be a rare cause of acute abdomen. Mostly its pathologies pre...