Significant Role of LGR-5 in Oral Cancer and Oral Dysplasia- A Review
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 10
Abstract
Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5) is a biomarker for cancer stem cell which has been responsible for the cancer development and progression. After the validation of LGR 5 as a marker of intestinal stem cells, the field has become more apparent and led to many new avenues of research. Recently, studies are also supported that LGR5 is overexpressed in diverse types of human cancers, including colorectal, gastric, esophageal, hepatocellular carcinomas and pancreatic adenocarcinoma. This emerging technology opens new possibilities of using cultured adult stem cells for drug development, disease modeling, gene therapy and regenerative medicine. This review describes the expression of LGR5 stem cells in HNSCC and summarizes subsequent progress, promises, unresolved issues, and challenges of the field.
Authors and Affiliations
Sabitha S, Jayashree Mohan, R. Madhavan Nirmal, Vasanthan P, Sathiya Jeeva J
Keywords
Related Articles
- EP ID EP549936
- DOI -
- Views 123
- Downloads 0
What Next - Career Motivations after Graduation in Dentistry the Present Scenario in India
Students are inspired to take up dentistry for factors related to security, social and professional status, financial rewards, better quality of life, and for working with people. The period of internship is the most sui...
Pediatric Oral Pigmented Lesions: A Short Review
Change in color of oral mucosa reflects the underlying health status, which is either local or systemic. Pigmentation is defined as the process of deposition of pigments in tissues. This color change is due to pigmentati...
Assessment of Dental Caries in subject’s age ranged 20- 60 years
Background: Dental caries is the most prevalent and chronic oral disease in children. The present study was conducted to determine dental caries status among patients ranged from 20- 60 years. Materials & Methods: The pr...
TWIRKLING SIGN IN DETECTION OF RENAL AND URETERAL STONE: A CLINICAL STUDY
Background: Kidney stone disease (urolithiasis) is when a solid piece of material (kidney stone) occurs in the urinary tract. The present study was conducted to compare standard gray scale ultrasound with color Doppler...
Comparative Assessment of Acute and Chronic Urticaria among patients visited in Dermatology Department
Background: Urticaria commonly presents with intensely pruritic wheals, sometimes with edema of the subcutaneous or interstitial tissue. Hence; we planned the present study to assess and compare the acute and chronic urt...