Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer Risk
Journal Title: Istanbul Medical Journal - Year 2020, Vol 21, Issue 5
Abstract
Introduction: To date, biomarkers have played a minimal role in the early diagnosis of breast cancer. Although its effects on metabolism are not well known, studies have shown that hypoadiponectinaemia is associated with increased insulin resistance and risk for type-2 diabetes. We aimed to investigate the value of adiponectin together with laboratory results, anthropometric measurements and histopathological findings in assessing the risk of breast cancer and for use in early diagnosis. Methods: In this study, serum samples were obtained from 59 recently diagnosed breast cancer patients and 47 cancerfree controls aged between 22 and 82 years to assay serum adiponectin, lipids, fasting blood glucose and insulin; homeostatic model assessment for insulin resistance (HOMA-IR) and body mass index were calculated using the anthropometric measurements. Histopathologic findings were extracted from the patients’ files. Results: Our results revealed that adiponectin serum levels and HOMA-IR values were significantly different between patients and controls. In addition, serum adiponectin levels were lower in postmenopausal breast cancer patients compared to the controls (p=0.03). Conclusion: In fact, a serum adiponectin level below 4.46 mg/L may be in favour of postmenopausal breast cancer (area under the curve =70%). However, Cerb-B2 expression in patients did not correlate with serum adiponectin levels. These findings have implications for further research on adiponectin as well as the in early diagnosis of postmenopausal breast cancer with possibly higher test sensitivity.
Authors and Affiliations
Turgut Aksoy, Didem Can Trabulus, Hale Aral, Erdinç Serin, Canan Kelten Talu
Keywords
Related Articles
- EP ID EP688646
- DOI 10.4274/imj.galenos.2020.92979
- Views 115
- Downloads 0
Neonatal Morbidity in Macrosomic Infants
Introduction: Macrosomy is defined as birth weight being over 4000 grams. Neonatal complications are common in macrosomic infants. In this study, we aimed to compare macrosomic infants with normal weighed infants in term...
Intraoperative Cholangiography in Laparoscopic Cholecystectomy: Technique and Changing Indications
Introduction: Although laparoscopic cholecystectomy (LC) is considered as the “gold standard” of cholecystectomy, the rate of bile duct injuries seems to be elevated when compared to open cholecystectomy. Intraoperative...
Insulinoma: Spectrum of Clinicopathological Features in a Tertiary Center
Introduction: Insulinoma is the most common functional neuroendocrine tumor of the pancreas. There are different methods for the preoperative localization of insulinoma, such as Computed Tomography (CT) scan, Magnetic Re...
Unexpected Histopathological Findings After Laparoscopic Sleeve Gastrectomy
Introduction: The prevalence of obesity is increasing all over the world. Laparoscopic sleeve gastrectomy (LSG) has become the most common bariatric surgery in the world today. Unlike other bariatric surgeries, laparosco...
Knowledge, Attitude and Practice Regarding Type 2 Diabetes Mellitus Among Outpatients in a Health Center in East-Coast of Peninsular Malaysia
Introduction: Type 2 diabetes mellitus (T2DM) is becoming a global epidemic and a threat to the world population. Methods: This cross-sectional study was carried out to assess the knowledge, attitude, and practice (KAP)...