Silymarin as potent Hepatoprotectants
Journal Title: The Journal of Phytopharmacology - Year 2012, Vol 1, Issue 3
Abstract
The hepatoprotective activity of silymarin has been evaluated in various chemicallyinduced models of hepatotoxicity, including carbon tetrachloride, thioacetamide, galactosamine, thallium, lead and cadmium poisoning, and in a biological model of Plasmodium berghei infection in Mastomys. The hepatotoxic effect of various substances is recognized mainly by the formation of free radicals through an activation process. Oxygen free radicals also play a significant role in hepatic intoxication through lipid peroxidation.
Authors and Affiliations
Madhusudan Upadhyaya
Keywords
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