SIMULTANEOUS DETERMINATION OF FLURBIPROFEN AND PANTOPRAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV SPECTROPHOTOMETER
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: A simple, rapid, precise and accurate spectrophotometric method has been developed for determination of Flurbiprofen and Pantoprazole by simultaneous equation method in combined dosage formMethods: The 6.8 pH phosphate buffer was selected as solvent for developing spectral characteristics of both drugs. The method was validated for recovery studies.Results: The λmax of Flubiprofen was found to be 230 nm and Pantoprazole was found to be 270 nm. The method obeyed Beer’s law in the concentration range of 10-100 μg/ml for Flurbiprofen and 10-100 μg/ml for Pantoprazole. The percentage recovery of Flubiprofen was found to be 99.16 and Pantoprazole was found to be 99.46.Conclusion: The proposed method was validated and can be used for analysis of combined tablet formulation containing Flurbiprofen and Pantoprazole.Â
Authors and Affiliations
Varaprasad Adepu, K. E. V Nagoji, V. Girijasastry
Keywords
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- EP ID EP579526
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