Simultaneous estimation of Curcumin and Gefitinib in bulk by using RP-HPLC technique with PDA detector.
Journal Title: Hygeia:journal for drugs and medicines - Year 2018, Vol 10, Issue 1
Abstract
Plan: RP-HPLC method development and validation for the simultaneous estimation of curcumin and Gefitinib in bulk. Preface: RP-HPLC chromatographic methods have been widely employed in the determination of individual components in a mixture or fixed dose combination. For the ternary mixture containing Curcumin and Gefitinib, no chromatographic method for simultaneous evaluation has been reported so far. Thus our aim is to develop a simultaneous estimation method for curcumin and gefitinib by using an RP-HPLC method using a PDA detector. Methodology: The method was validated as per ICH guidelines. The recovery studies confirmed the accuracy and precision of the method. Outcome: The proposed method was found to be accurate, repeatability and consistent. It was successfully applied for the analysis of the drug in the marketed formulation and could be effectively used for the routine analysis of formulation containing the drug without any alteration in the chromatography conditions.
Authors and Affiliations
Sagar Kishor Savale
Keywords
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- EP ID EP391898
- DOI 10.15254/H.J.D.Med.10.2018.172.
- Views 70
- Downloads 0
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