SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE, PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE BY DERIVATIVE SPECTROPHOTOMETRY METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The simple and accurate method of analysis to determine Glimepride (GLM), Pioglitazone hydrochloride (PIO) and Metformin hydrochloride (MET) in combined dosage forms was developed using second-derivative spectrophotometry and. GLM, PIO and MET in combined preparations (tablets) were quantified using the second-derivative responses at 233.4 nm for GLM, 265.4 nm for PIO and 252.6 nm for MET in spectra of their solutions in methanol. The calibration curves were linear [correlation coefficient (r) = 0.9990 for GLM, 0.9990 for PIO and 0.9990 for MET] in the concentration range of 5-25 μg/ml for GLM, 5–25 μg/ml for PIO and 2–12 μg/ml for MET. The method was validated and found to be accurate, precise, and specific. The method was successfully applied to the estimation of GLM, PIO and MET in combined tablet formulations.
Authors and Affiliations
Deepa Patel , Laxmanbhai Patel , Madhabhai Patel , Advaita Patel
Keywords
Related Articles
- EP ID EP86410
- DOI -
- Views 165
- Downloads 0
FORMULATION AND ASSESSMENT OF GEMIFLOXACIN MESYLATE OCULAR IN SITU GELLING SYSTEM
In situ gels are one of the most successful means of delivering the drug at ocular site with maximum bioavailability, which undergoes gelation upon instillation as drops into the eye due to physicochemical changes inhere...
DEGRADATION STUDY OF FIVE DIFFERENT BRANDS OF CIPROFLOXACIN USING UV VISIBLE SPECTROPHOTOMETER AND THEIR COMPARATIVE STUDY
Degradation studies help to anticipate the future stability issue the drug product may undergo, and provide useful information for both formulation and stability. We explored the degree of degradation in five different b...
A PRELIMINARY PHARMACOGNOSTICAL AND PHYSICOCHEMICAL ASSAY OF SHUNTHI KHANDA GRANULES
Shunthi (Zingiber officinale Roscoe) is a drug with multi-dimensional activities mentioned in Ayurvedic classics for different disease conditions. Ayurvedic pharmacopeia also holds a number of formulations where Shunthi...
FORMULATION AND EVALUATION OF PULSED DRUG DELIVERY OF 5- FLUOROURACIL IN TREATING COLO-RECTAL CANCER
The proposed work aimed to develop a time dependent programmable pulsatile drug delivery system of 5-Fluorouracil, intended for chronotherapy in colorectal cancer. Various batches of tablets were prepared by direct compr...
PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY STUDY OF SARACA INDICA LEAVES EXTRACT
To know the role of different phytochemicals in relation to the in vitro antibacterial activity of both the ethanolic and methanolic extracts of Saraca indica (Family-Caesalpinaceae), present study was conducted. Followi...