SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE, PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE BY DERIVATIVE SPECTROPHOTOMETRY METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The simple and accurate method of analysis to determine Glimepride (GLM), Pioglitazone hydrochloride (PIO) and Metformin hydrochloride (MET) in combined dosage forms was developed using second-derivative spectrophotometry and. GLM, PIO and MET in combined preparations (tablets) were quantified using the second-derivative responses at 233.4 nm for GLM, 265.4 nm for PIO and 252.6 nm for MET in spectra of their solutions in methanol. The calibration curves were linear [correlation coefficient (r) = 0.9990 for GLM, 0.9990 for PIO and 0.9990 for MET] in the concentration range of 5-25 μg/ml for GLM, 5–25 μg/ml for PIO and 2–12 μg/ml for MET. The method was validated and found to be accurate, precise, and specific. The method was successfully applied to the estimation of GLM, PIO and MET in combined tablet formulations.
Authors and Affiliations
Deepa Patel , Laxmanbhai Patel , Madhabhai Patel , Advaita Patel
DIURESIS: EXPERIMENTAL EVIDENCE OF POLYHERBALS IN ALBINO RATS
Numerous medicinal plants and their formulations are used for various disorders in ethno medical practices as well in the traditional system of medicine in India. The Vrukkadoshantake vati (VV) and Nephrovin (NEP) are ay...
LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN SOUTH INDIAN PATIENTS WITH TYPE 2 DIABETES MELLITUS
An imbalance between reactive oxygen species production and antioxidant scavenging has been implicated in type 2 diabetes. Reports indicate that several complications of diabetes mellitus are associated with increased ac...
PHYTO-PHARMACOLOGICAL REVIEW OF ARGYREIA NERVOSA
Herbal medicines are the significant and reliable sources for treating various diseases. Argyreia nervosa is traditionally used in wound healing, syphilius,diuretics,rheumatic affections, leucohorrhoea.,cerebral disord...
SYNTHESIS AND ANTHELMINTIC ACTIVITY OF 3-(2-HYDRAZINO BENZOTHIAZOLES)-SUBSTITUTED INDOLE-2-ONE
Benzothiazoles and Isatins have emerged as structurally novel anthelmintics. Therefore various 3-(2-hydrazino benzothiazoles)-substituted Indole-2-one, were synthesized by condensation of various 2-hydrazino benzothiazol...
AN OVERVIEW OF GASTRORETENTIVE DRUG DELIVERY SYSTEM RESEARCH
The reason of writing this research article on gastro retentive drug delivery systems was to gather the recent literature with special focus on various gastro retentive approaches that have recently become leading method...