SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE, PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE BY DERIVATIVE SPECTROPHOTOMETRY METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The simple and accurate method of analysis to determine Glimepride (GLM), Pioglitazone hydrochloride (PIO) and Metformin hydrochloride (MET) in combined dosage forms was developed using second-derivative spectrophotometry and. GLM, PIO and MET in combined preparations (tablets) were quantified using the second-derivative responses at 233.4 nm for GLM, 265.4 nm for PIO and 252.6 nm for MET in spectra of their solutions in methanol. The calibration curves were linear [correlation coefficient (r) = 0.9990 for GLM, 0.9990 for PIO and 0.9990 for MET] in the concentration range of 5-25 μg/ml for GLM, 5–25 μg/ml for PIO and 2–12 μg/ml for MET. The method was validated and found to be accurate, precise, and specific. The method was successfully applied to the estimation of GLM, PIO and MET in combined tablet formulations.
Authors and Affiliations
Deepa Patel , Laxmanbhai Patel , Madhabhai Patel , Advaita Patel
Keywords
Related Articles
- EP ID EP86410
- DOI -
- Views 158
- Downloads 0
ANTIMICROBIAL POTENCY SCREENING OF CLERODENDRUM INFORTUNATUM LINN.
Plants play a major role in all the traditional system of medicine. Plants contain the rich source of natural products like vitamins, minerals and other immune-modulators. Most of which have been used for human welfare s...
BAUHINIA TOMENTOSA: A PHYTOPHARMACOLOGICAL REVIEW
Bauhinia tomentosa commonly known as Yellow bell orchid tree belongs to Fabaceae family, one of the best, versatile and most commonly used household remedy for many manifestations. It is an erect shrub with downy branche...
STABILITY EVALUATION OF TOPICAL OINTMENT COMPRISING CALCIPOTRIOL AND PREDNICARBATE
Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. The objective of...
EVALUATION AND COMPARISON OF ANXIOLYTIC EFFECT OF FLAXSEED OIL AND PERILLA OIL IN MICE
The Purpose of this study was to evaluate and compare the putative anxiolytic-like activity of Flaxseed Oil and Perilla Oil using elevated plus maze (EPM) and light-dark exploration test in mice. Flaxseed Oil is also kno...
GASTRO PROTECTIVE EFFECTS OF FICUS DALHOUSIAE MIQ ROOTS ETHANOLIC EXTRACT IN INDOMETHACIN AND COLD RESTRAINT STRESS INDUCED ULCERS
The aim of the present study was to evaluate the gastro protective effects of FDREE in Indomethacin and cold restraint stress induced ulcer models. Wistar albino rats were employed in the study. The preliminary phytochem...