Simultaneous estimation of xanthine alkaloids (Theophylline, Theobromine and Caffeine) by High-Performance Liquid Chromatography
Journal Title: International Journal of Drug Regulatory Affairs - Year 2019, Vol 7, Issue 2
Abstract
Methylxanthines are mainly a group of phytochemicals which are derived from purine base xanthine. These xanthines are obtained from plant as a result of secondary metabolism. There are various physiological actions that have been attributed to these derivatives in neurogenerative diseases, respiratory diseases, cancer and diabetes. The aim of this study is to develop a suitable qualitative and quantitative method for these xanthine derivatives. HPLC method is suitable for simultaneous estimation of methylxanthines, based on their physicochemical properties. Theobromine, Theophylline and Caffeine that belongs to alkaloids possess their economic effects. They have various stimulant effects on cardiovascular system, gastrointestinal system, respiratory system, central nervous system etc. that results in increased motivation to work, increased energy and increased alertness. High performance liquid chromatography is used for simultaneous determination of theophylline, theobromine and caffeine from different tea leaves.
Authors and Affiliations
Shruti Mourya, Ramesh Bodla, Ravikant Taurean, Akanksha Sharma
COMPLEX GENERICS: OPPORTUNITIES & CHALLENGES
Now a day, big pharmaceutical companies with sustainable revenues are more interested in complex products to minimize competitions. In line with the originator companies, many generic companies are also focusing on compl...
REGULATIONS OF ORPHAN DRUGS IN USA, EU AND INDIA-A COMPARATIVE STUDY
Orphan drugs are the drugs and natural products used in treatment, diagnosis, or prevention of rare disease. The orphan drug regulation varies in different countries. Initially a guideline (Orphan Drug Act) for orphan dr...
GENERIC MEDICINES REGULATION IN BRAZIL
The regulation of medicines in Brazil has proven to be one of the major concerns of government policies in recent decades. In order to improve access to quality medicines for the population, the National Drug Policy was...
DRUG REGULATION IN INDIA: SWOT ANALYSIS
Drug regulation plays pivotal role in any country because the purpose of drug regulation is to promote and to protect public health by ensuring the safety, efficacy and quality of drugs. Drug regulation should cover all...
TRIPS AND INDIAN PHARMACEUTICAL INDUSTRY
The TRIPs Agreement has led to a reinforcement of the protection of intellectual property, particularly in many developing countries. From the point of view of transfer of technology, the imitation of technologies from i...