Simultaneous Pharmacokinetic Model for Rolofylline and both M1-trans and M1-cis Metabolites
Journal Title: The AAPS Journal - Year 2013, Vol 15, Issue 2
Abstract
The online version of this article (doi:10.1208/s12248-012-9443-5) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Mark Stroh, Matthew M. Hutmacher, Jianmei Pang, Ryan Lutz, Hiroshi Magara, Julie Stone
Effects of Replacement of Factor VIII Amino Acids Asp519 and Glu665 with Val on Plasma Survival and Efficacy In Vivo
Proteolytic cleavage of factor VIII (FVIII) to activated FVIIIa is required for participation in the coagulation cascade. The A2 domain is no longer covalently bound in the resulting activated heterotrimer and is highly...
Interaction of dicaproyl phosphatidylserine with recombinant factor VIII and its impact on immunogenicity
Replacement therapy with exogenous recombinant factor VIII (rFVIII) to control bleeding episodes results in the development of inhibitory antibodies in 15% to 30% of hemophilia A patients. The inhibitory antibodies are m...
Lower Exposure and Faster Clearance of Bevacizumab in Gastric Cancer and the Impact of Patient Variables: Analysis of Individual Data from AVAGAST Phase III Trial
The online version of this article (doi:10.1208/s12248-014-9631-6) contains supplementary material, which is available to authorized users.
Peptidomics of the Prolyl Peptidases
The prolyl peptidases are a family of enzymes characterized by a biochemical preference for cleaving proline-containing peptides. The members of this enzyme family include prolyl endopeptidase, prolyl endopeptidase-like,...
Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water
The online version of this article (doi:10.1208/s12248-015-9729-5) contains supplementary material, which is available to authorized users.