SIMULTANEOUS RATIO DERIVATIVE SPECTROPHOTOMETRIC ESTIMATION OF ACECLOFENAC AND TIZANIDINE WITH PARACETAMOL IN COMBINATION SOLID DOSAGE FORMS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
A derivative spectrophotometric procedure has been developed for the simultaneous determination of individual combination of Aceclofenac and Tizanidine with Paracetamol in combined tablet preparation. Tablet extracts of the drugs were prepared in methanolic distilled water (50:50ml) the zero crossing point technique and the compensation technique were used to estimate the amount of each drug in the combined formulations, and were compared. The results were found to be accurate and free from interferences. The procedure is rapid, simple, nondestructive, and does not require solutions of equations. Calibration graphs are linear (r=0.9999), with a zero intercept up to 25 mg/ml of each drug in combination with paracetamol. Detection limits at the p = 0.0585 level of significance were calculated to be 0.58 mg/ml of aceclofenac, tizanidine and paracetamol respectively.
Authors and Affiliations
Agasti Ware , Sunil Aher , Deepak Musmade , Suwarna Gajare , Poonam Patil
Keywords
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