SIMULTANEOUS RP-HPLC DETERMINATION OF CEFPODOXIME PROXETIL AND OFLOXACIN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 9
Abstract
A rapid and simple high Reverse-phase performance liquid chromatography method was developed and validated for simultaneous determination of Cefpodoxime Proxetil and Ofloxacin from pharmaceutical preparation. The separation was achieved on A kromosil (technokroma) 100 C-8 (3.5μm ,15x0.46) performed using Acetonitrile and phosphate buffer as mobile phase the of pH of buffer was adjusted to 4.8 using Ortho-phosphoric acid, the ratio was 58:42 (v/v) eluents were monitored at 275 nm. The detector response was linear in the range of 100 to 300 μg, for both Cefpodoxime Proxetil and Ofloxacin. The percentage assay Cefpodoxime Proxetil and Ofloxacin was found between 99.76 and 99.31% respectively. The described method has the advantage of being rapid and easy hence it can be applied for routine quality control analysis.
Authors and Affiliations
Shrikant Ainwale , Vaibhav Chipade, Anil Dewani, R. L. Bakal, M. R. Shiradkar, A. V. Chandewar
Keywords
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- EP ID EP143342
- DOI 10.7897/2230-8407.069132
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