SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF RABEPRAZOLE SODIUM AND DOMPERIDONE MALEATE IN CAPSULES BY CHEMOMETRIC METHODS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 6
Abstract
Simultaneous spectrophotometric determination of Rabeprazole sodium and Domperidone maleate was performed by partial least-squares (PLS) and principal component regression (PCR) methods do not require any priori graphical treatment of the overlapping spectra of two drugs in the mixture. The absorbance values in the UV-Vis spectra were measured for the 89 wavelength points (from 221-309) in the spectral region 200-400nm considering the intervals of 1nm. The calibration range was found to be 4-20μg/ml for Rabeprazole sodium, 6-30μg/ml for Domperidone maleate with a correlation coefficient of 0.9999 (PLS), 0.9999 (PCR) for Rabeprazole sodium and 0.9999 (PLS), 0.9999 (PCR) for Domperidone maleate. The validation of the multivariate methods was realized by analyzing the synthetic mixtures of Rabeprazole sodium and Domperidone maleate. The numerical calculations were performed with the ‘Unscrambler 10.1X’ software. The chemometrics analysis methods were satisfactorily applied to the simultaneous determination of Rabeprazole sodium and Domperidone maleate in the pharmaceutical formulation.
Authors and Affiliations
Vijayageetha Ragupathy, Shantha Arcot
Keywords
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