Single dose amoxicillin induced toxic epidermal necrolysis – A rare life threatening dermatological condition
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 4
Abstract
Toxic epidermal necrolysis is a severe cutaneous drug reaction, mainly involving skin and mucous membranes. We have presented here a case report of 16 year old female patient who was diagnosed with toxic epidermal necrolysis clinically as well as histopathologically. The patient presented with history of fever, oral cavity ulcer, skin lesions which were ill defined, erythematous macular with darker hemorrhagic centre. Skin biopsy showed full thickness necrosis of dermis, dermal-epidermal separation and paucity of upper dermal cellular infiltration. The patient was treated with intravenous immunoglobulins, low dose steroids and systemic antibiotics and the patient improved significantly. The main purpose of the case report was to emphasize that even one single dose of amoxycillin can induce a toxic epidermal necrolysis.
Authors and Affiliations
Sunil Pathak, Mukesh Nagar, Mahendra Kavad, Harshil Patel, Kalpic Patel, Maitray Patel
Keywords
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