SINUS HISTIOCYTOSIS AND MASSIVE LYMPHADENOPATHY (ROSAI-DORFMAN DISEASE) IN AN 8 YEAR OLD FEMALE CHILD: A RARE CASE REPORT
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 1
Abstract
Introduction: Sinus histiocytosis with massive lymphadenopathy is an infrequent, self-resolving histoproliferative disorder of benign nature, also known as Rosai–Dorfman Disease. The typical manifestation of this disease includes bilateral, progressive cervical lymphadenopathy along with pyrexia. Laboratory manifestations consist of raised erythrocyte sedimentation rate, leukocytosis and hypergammaglobulinemia. Case report: An 8 year old female child presented with progressive, painful cervical and submandibular lymphadenopathy of three months duration. There was polymorphic leukocytosis and anemia along with raised Erythrocyte sedimentation rate and hypergammaglobulinemia. Fine Needle Aspiration cytology revealed sinus histiocytosis with massive lymphadenopathy, which was confirmed by the cervical lymph node biopsy. The histopathology revealed dilated sinuses filled with lympho plasma cells, large histiocytes and engulfed neutrophils (Emperipolesis). Conclusion: Massive, progressive bilateral cervical and sub mandibular lymphadenopathy, suggesting Sinus histiocytosis and massive lymphadenopathy-Rosai–Dorfman Disease. This was confirmed by Cytology, histopathology and immuno- histochemistry.
Authors and Affiliations
Uppin Narayan Reddy| Professor and Head, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Corresponding author email: janampalli.ravikiran@gmail.com, Swathi Chacham| Associate Professor, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Janampally Ravikiran| Junior Resident, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Jillalla Narsing Rao| Professor, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Jakkampudi Nagasravani| Junior Resident, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Abhijeet Ingle| Department of pathology, Yashoda Hospital, Malakpet, Hyderabad, Telangana, India
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- EP ID EP11381
- DOI 10.5958/2319-5886.2015.00047.8
- Views 262
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