SINUS HISTIOCYTOSIS AND MASSIVE LYMPHADENOPATHY (ROSAI-DORFMAN DISEASE) IN AN 8 YEAR OLD FEMALE CHILD: A RARE CASE REPORT
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 1
Abstract
Introduction: Sinus histiocytosis with massive lymphadenopathy is an infrequent, self-resolving histoproliferative disorder of benign nature, also known as Rosai–Dorfman Disease. The typical manifestation of this disease includes bilateral, progressive cervical lymphadenopathy along with pyrexia. Laboratory manifestations consist of raised erythrocyte sedimentation rate, leukocytosis and hypergammaglobulinemia. Case report: An 8 year old female child presented with progressive, painful cervical and submandibular lymphadenopathy of three months duration. There was polymorphic leukocytosis and anemia along with raised Erythrocyte sedimentation rate and hypergammaglobulinemia. Fine Needle Aspiration cytology revealed sinus histiocytosis with massive lymphadenopathy, which was confirmed by the cervical lymph node biopsy. The histopathology revealed dilated sinuses filled with lympho plasma cells, large histiocytes and engulfed neutrophils (Emperipolesis). Conclusion: Massive, progressive bilateral cervical and sub mandibular lymphadenopathy, suggesting Sinus histiocytosis and massive lymphadenopathy-Rosai–Dorfman Disease. This was confirmed by Cytology, histopathology and immuno- histochemistry.
Authors and Affiliations
Uppin Narayan Reddy| Professor and Head, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Corresponding author email: janampalli.ravikiran@gmail.com, Swathi Chacham| Associate Professor, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Janampally Ravikiran| Junior Resident, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Jillalla Narsing Rao| Professor, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Jakkampudi Nagasravani| Junior Resident, Department of Pediatrics Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Abhijeet Ingle| Department of pathology, Yashoda Hospital, Malakpet, Hyderabad, Telangana, India
Keywords
Related Articles
- EP ID EP11381
- DOI 10.5958/2319-5886.2015.00047.8
- Views 290
- Downloads 12
Evaluating the reliability of ultrasonographic parameters in differentiating benign from malignant superficial lymphadenopathy
Diagnosis of malignant lymphadenopathy is of particular importance for treatment planning, before treatment staging and also for prognosis determination. Currently various diagnostic procedures are used to differentiate...
The Study of Eating Disorders and Body Image Among Elite Martial Arts Athletes
Study objective: The competitive sports environment can enhance social and cultural pressure towards having ideal body weight in weight-sensitive sports. The close relationship between body image and performance makes t...
ANGIOMYOLIPOMA OF A KIDNEY: A CASE REPORT
Angiomyolipoma is a rare benign tumour of the kidney. They are composed of abnormal vasculature, smooth muscle and adipose elements. They may be associated with Tuberous sclerosis. The unilateral presentation is uncomm...
PERSISTENT ARRHYTHMIAS AFTER ELECTROCUTION IN A PATIENT SCHEDULED FOR GRAFT SURGERY
PVC may occur due to numerous etiologies. Manifestations may range from an asymptomatic presentation to ventricular fibrillation and death. The incidence of PVC in healthy population may range from 0.5% in those aged b...
Influence of Gluteus Maximus Inhibition on Upper Trapezius Overactivity in Chronic Mechanical Neck Pain with Radiculopathy
Background: Mechanical neck pain is the most common type of neck pain and commonly to accompany with radiculopathy. Patients of neck pain exhibit greater activation of accessory muscles, (sternocleidomastoid, anterior...