Sitagliptin Versus Metformin as an Initial Monotherapy in Type 2 Diabetes Mellitus Patients - Observational Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 10
Abstract
Introduction: Diabetes mellitus is a chronic metabolic disease. So an Observational study Comparing sitagliptin to metformin as an initial monotherapy in type 2 diabetes mellitus patients. Diabetes mellitus is a chronic, progressive disease and lifestyle modifications alone are inadequate, one or more agents are usually required to attain adequate glycemic control. Material and methods: In the present study 200 known diabetic patients were selected and these patients were randomly divided into two groups, group A comprised 100 patients whose baseline glycemic parameters were recorded and patients were put on sitagliptin 100 mg per day, whereas Group B comprised of 100 patients and these patients were placed on metformin 500mg – 2000 mg per day to achieve glycemic control and repeat testing for HbA1c was done after 24 weeks, patients were monitored closely for ensuring the compliance to diet, drug and exercise. Results: These 200 patients were randomly divided into two groups, Group A comprised 100 patients were put on sitagliptin 100 mg per day, Group B comprised 100 patients were selected and were placed on metformin 500mg – 2000mg. Both the groups baseline FBS, PLBS, HBa1C was estimated prior to the study. It was observed that the mean baseline HBA1c in the Group A patients was 7.85% and in Group B was 7.99%, whereas the mean HbA1c after 24 weeks of therapy was 7.49% and 7.80% respectively in the Group A and B. There was a significant decrease in HBA1c in both the groups and it was statically significant. Conclusion: In this 24 week study sitagliptin was not inferior compared to metformin in controlling the Hba1C in patients with type 2 diabetes mellitus. In summary, both sitagliptin or metformin monotherapy helped in improving glycemic control in patients with type 2 diabetes mellitus. Both the group of the drugs was well tolerated by the patients, and the incidence of gastrointestinal-related adverse effects was there but it lower, whereas the weight loss was low in the sitagliptin group of patients. The result of this study provides the data for the use of sitagliptin as initial monotherapy for type 2 diabetes mellitus patients.
Authors and Affiliations
Gururaj Krishnarao Kulkarni, Jaishree Prabhakar
Keywords
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