Sitagliptin Versus Metformin as an Initial Monotherapy in Type 2 Diabetes Mellitus Patients - Observational Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 10
Abstract
Introduction: Diabetes mellitus is a chronic metabolic disease. So an Observational study Comparing sitagliptin to metformin as an initial monotherapy in type 2 diabetes mellitus patients. Diabetes mellitus is a chronic, progressive disease and lifestyle modifications alone are inadequate, one or more agents are usually required to attain adequate glycemic control. Material and methods: In the present study 200 known diabetic patients were selected and these patients were randomly divided into two groups, group A comprised 100 patients whose baseline glycemic parameters were recorded and patients were put on sitagliptin 100 mg per day, whereas Group B comprised of 100 patients and these patients were placed on metformin 500mg – 2000 mg per day to achieve glycemic control and repeat testing for HbA1c was done after 24 weeks, patients were monitored closely for ensuring the compliance to diet, drug and exercise. Results: These 200 patients were randomly divided into two groups, Group A comprised 100 patients were put on sitagliptin 100 mg per day, Group B comprised 100 patients were selected and were placed on metformin 500mg – 2000mg. Both the groups baseline FBS, PLBS, HBa1C was estimated prior to the study. It was observed that the mean baseline HBA1c in the Group A patients was 7.85% and in Group B was 7.99%, whereas the mean HbA1c after 24 weeks of therapy was 7.49% and 7.80% respectively in the Group A and B. There was a significant decrease in HBA1c in both the groups and it was statically significant. Conclusion: In this 24 week study sitagliptin was not inferior compared to metformin in controlling the Hba1C in patients with type 2 diabetes mellitus. In summary, both sitagliptin or metformin monotherapy helped in improving glycemic control in patients with type 2 diabetes mellitus. Both the group of the drugs was well tolerated by the patients, and the incidence of gastrointestinal-related adverse effects was there but it lower, whereas the weight loss was low in the sitagliptin group of patients. The result of this study provides the data for the use of sitagliptin as initial monotherapy for type 2 diabetes mellitus patients.
Authors and Affiliations
Gururaj Krishnarao Kulkarni, Jaishree Prabhakar
Keywords
Related Articles
- EP ID EP424273
- DOI -
- Views 100
- Downloads 0
A Study to Confirm the Position of Endotracheal Tube using Ultrasonography and Standard Auscultation Method
Introduction: Endotracheal intubation is a life saving procedure that is routinely performed by anesthesiologist, emergency medicine physicians and critical care physicians. Study aimed to confirm the position of endotra...
Time and Predicting Factors of Non-compliant TB Patients to Default Treatment - A Perspective from Sudan - 2016
Introduction: Tuberculosis is a chronic infectious disease that requiring prolonged course of treatment. The Treatment regimens recommended under Sudan National Tuberculosis Program have shown to be effective, but poor c...
A Study of Bacteriology in Chronic Suppurative Otitis Media with Cholesteatoma Cases
Introduction: Chronic suppurative otitis media with cholesteatoma is typically a persistent disease. Insidious in onset, often capable of causing severe destruction and irreversible sequela and clinically it manifests wi...
Clinicopathological Study of Significant Cervical Lymphadenopathy in Children
Introduction: Lymphadenopathy is a common problem in children and evaluation of child with lymphadenopathy is a common clinical scenario for the paediatrician, lymphadenopathy in children may be due to systemic infection...
Effect of Different Irrigation Devices on Removal of Smear Layer - A Systematic Review
Introduction: Various irrigation activation methods have been developed in order to provide effective delivery of irrigant. Effective irrigant delivery and agitation are prerequisites to promote root canal disinfection a...