Sjögren's syndrome – a complete literature preview
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 12
Abstract
Sjögren’s syndrome (SS) is a complex, chronic, systemic, autoimmune disease that mainly affects the exocrine glands, especially the salivary and lacrimal glands, leading to dryness of the oral and ocular mucosae. Several factors have been studied that could explain the glandular hypofunction primarily related to water transport. Sjögren’s syndrome (SS) is characterized by keratoconjunctivitis sicca, xerostomia and rheumatoid arthritis. Salivary gland dysfunction in one of the key manifestations of this disease and thus it seems logical to use the dysfunction of these glands for its diagnosis. A growing number of researchers from various fields including dentistry are finding saliva as a useful diagnostic tool due to easy and noninvasive collection methods. Recent reports have shown alterations in secretory route and trafficking in labial salivary glands, explaining alterations in the saliva quality. The decrease in salivary flow and qualitative alterations in saliva could explain many of the oral manifestations. The exocrine manifestations and systemic involvement significantly impact the patient’s perception of health-related quality of life. The non-invasive nature of saliva makes it the most reliable and favored tool for diagnosis of SS. The ability to measure a wide range of molecular components in saliva and compare them with serum has made it feasible to study microbes, chemicals and immunological markers. This review article aims at summarizing the variable use of saliva as a diagnostic aid on a daily basis while treating patients with SS.
Authors and Affiliations
Dr. Hima Desai, Dr. Ankit Shah, Dr Peshal Patel
Keywords
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