SLE and Tuberculosis: A Case Series and Review of Literature
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 2
Abstract
Systemic Lupus Erythematosus (SLE) and Tuberculosis (TB) are intricately related with an increase in the risk of TB in SLE. Primary mechanisms pertaining to the increased susceptibility for TB are the inherent immunodeficient state of SLE and use of immunosuppressant agents in the treatment of SLE. We report a case series of five female patients of SLE with TB who presented between January 2015 and December 2015 in a tertiary care teaching hospital in North Eastern India. All the patients were young to middle aged females having SLE with or without lupus nephritis who were on immunosuppressive therapy with corticosteroids, mycophenolate mofetil or cyclophosphamide. Two of the cases had sputum positive pulmonary tuberculosis while rest had Extra-Pulmonary TB (EPTB). The response to anti-tubercular therapy led to clinical improvement in all the cases except one who had an adverse outcome. Our series further substantiates the increased risk of TB in SLE thus, prompting further research towards better management of these two disease entities in conjunction.
Authors and Affiliations
Prasanta Kumar Bhattacharya, Md Jamil, Aakash Roy, Kishore Kumar Talukdar
Knee X-Ray in Short Stature: Helpful Indicator to Diagnose SHOX Deficiency
Images in Medicine
Pneumococcal Vaccination among Adults with Respiratory Diseases-Indications, Adherence and Roadblocks
ABSTRACT Introduction: Globally, invasive pneumococcal disease poses a major challenge to the health system and causes significant economic burden. Pneumococcal vaccination is a recommended and well adhered practice amon...
Serial Changes in Complete Blood Counts in Patients with Leptospirosis: Our Experience
Introduction: Leptospirosis is an infectious disease caused by Leptospira interrogans. It is endemic in many parts of the world. The symptoms vary between milder forms to severe type with organ dysfunction. The disease p...
Crigler Najjar Syndrome Type 2 (CNS Type 2): An Unwonted Cause of Jaundice in Adults
Crigler Najjar Syndrome (CNS) Type 2 is an uncommon genetic disorder characterised by non-haemolytic unconjugated hyperbilirubinemia. It is caused by mutations in the UGT1A1 gene which codes for the enzyme uridine diphos...
Effect of the Sexual Education Program on the Knowledge and Attitude of Preschoolers’ Mothers
ABSTRACT Introduction: Sexual instinct needs education and training similar to other aspects of the human life. Education can promote changes in knowledge and attitudes of parents, especially mothers. Education has a mai...