SLE – vasculitis – cold hemagglutinin disease (CHAD)
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2015, Vol 32, Issue 1
Abstract
Laboratory tests were as follows: Hct=21.3%, Hb=6.1 g/dL, WBC=2,800/μL (neutrophils 38%, lymphocytes 50%, monocytes 12%), reticulocytes=6.1% and platelets=144.000/μL. Peripheral blood smears is shown in figures 2 and 3. Blood chemistry was Glu=1.50 mg/dL, BUN=0.70 mg/dL, creatinine=0.9 mg/dL, Na+=135 mmol/L, K+=4.0 mmol/L, Ca++=4.6 mEq/L, SGOT=26 IU/L, SGPT=16 IU/L, bilirubin=2.52 mg/dL (indirect 1.8 mg/dL), ALP=105 IU/L, γGT=32 IU/Ι, uric acid=5.5 mg/dL, LDH=1,070 IU/L, CPK=10 IU/L. Total protein was 7.3 g/L (alb=3 g/L, α1-globulins=0.3,An 80-year-old man presented to the outpatient clinic with fatigue, difficulty in breathing, heartburn, chest pain and palpitations in effort, pain in fingers and toes during last week and α2-globulins=0.3, β-globulins=0.7 and γ-globulins=2.5 g/L). The coagulation tests were normal (PT=11 sec, APTT=30 sec, fibrinogen=230 mg/dL). Direct Coombs test was positive for ΙgG, ΙgA, ΙgM, and C3: indirect Coombs test was also positive. Antibodies for Mycoplasma, EBV and other viruses were negative. ANA, anti-DNA tests were positive. Urine chemistry and microscopy were normal. hemorrhagic dermal rash, especially in the lower extremities (fig. 1). There was a history of mild anemia and attacks of acrocyanosis (blue discoloration of fingers and toes following exposure in cold) for the last ten years. A chronic, non-paramorphotic arthritis of the hands was diagnosed ten years ago with mild cervical lympadenopathy and mild splenomegaly. No abnormal findings were detected in the CT of upper and lower abdomen, and of the chest. Physical examination revealed pallor, tachycardia, splenomegaly (2 cm below the left costal margin), and hepatomegaly (one centimeter below the right costal margin). Mild cervical and axillar lympadenopathy were detected. Physical examination was otherwise unremarkable.
Authors and Affiliations
J. ASIMAKOPOULOS, L. PAPAGEORGIOU, K. PETEVI, G. BOUTSIKAS, P. FLEVARI, E. KOUTSI, V. TELONIS, A. ZANNOU, T. VASSILAKOPOULOS, M. ANGELOPOULOU
Keywords
Related Articles
- EP ID EP137420
- DOI -
- Views 129
- Downloads 0
Epidemiology of pulmonary tuberculosis among patients of two hospitals in Athens
OBJECTIVE Despite its profound clinical significance and worldwide resurgence, the epidemiology of pulmonary tuberculosis (TB) among adults in Greece is poorly defined. The goal of this study was to collect relevant epid...
Physical activity of 28,030 men and women of the Greek EPIC cohort
OBJECTIVE The assessment of the physical activity of the Greek EPIC population. METHOD A standardized, closed-ended, interviewer administered physical activity questionnaire was used to assess the participation of th...
In vivo nephrogenesis in Lewis rats from endothelial cells of syngeneic liver grafts transplanted into partially excised kidney: The role of transforming growth factor (TGF)-β1 and Thy-1 (CD90)
OBJECTIVE In vitro nephrogenesis using the own tissues is an ideal substitute for allogeneic whole-kidney transplantation. METHOD Adult Lewis rats were transplanted syngeneic liver structure grafts, from which hepatoc...
Hydroxyapatite-coated total hip arthroplasty: The impact on survival and thigh pain
OBJECTIVE The purpose of this study was to evaluate the long term clinical outcome of primary total hip arthroplasty using an uncemented, hydroxyapatite-coated implant. METHOD A consecutive series of 164 patients (176...
Investigation of the culture of safety in the medical and surgical wards of a general hospital
OBJECTIVE To investigate the patient safety culture and associated factors in medical and surgical wards in a tertiary general hospital in Cyprus. METHOD Data were collected from health care professionals working in t...